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IDH2 wt Allele

Known as: IDH, IDP, ICD-M 
Human IDH2 wt allele is located in the vicinity of 15q26.1 and is approximately 18 kb in length. This allele, which encodes isocitrate dehydrogenase… 
National Institutes of Health

Related topics

Related topics

14 relations
15q26.1AstrocytomaGlioblastoma, IDH-MutantHomo sapiens

Broader (1)

IDH2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Termite diversity along a land use intensification gradient in a semi-arid savanna
Disturbance, particularly agricultural expansion is one of the major threats to the biodiversity and ecological functions of… 
2012
2012
IDH 1 and IDH 2 Mutations in Tumorigenesis : Mechanistic Insights and Clinical Perspectives
Genes encoding for isocitrate dehydrogenases 1 and 2, IDH1 and IDH2, are frequently mutated in multiple types of human cancer… 
2012
2012
Long-term follow-up results of EORTC 26951: A randomized phase III study on adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors (AOD).
2 Background: AOD are chemotherapy-sensitive tumors especially if 1p/19q co-deleted. Between 1995 and 2002 the EORTC Brain Tumor… 
2012
2012
IDH mutations: new genetic signatures in cholangiocarcinoma and therapeutic implications
“Theoretically, specific targeting of neomorphic isocitrate dehydrogenase activity with small molecule inhibitors could minimize… 
Review
2011
Review
2011
Isocitrate dehydrogenase mutations: A challenge to traditional views on the genesis and malignant progression of gliomas
Isocitrate dehydrogenases (IDHs) convert isocitrate to α‐ketoglutarate by oxidative decarboxylation and are thereby involved in… 
2011
2011
Isolated del(5q) in myeloid malignancies: Clinicopathologic and molecular features in 143 consecutive patients
World Health Organization (WHO) criteria were used to identify 143 consecutive patients (median age 73 years; 90 females) with… 
Review
2009
Review
2009
Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum
•  Introduction •  Lessons from a rare disease •  Specificity of function within the EglN prolyl hydroxylases •  Failure of EglN3… 
2007
2007
Mitochondrial isocitrate dehydrogenase protects human neuroblastoma SH‐SY5Y cells against oxidative stress
The neuroprotective effect of mitochondrial isocitrate dehydrogenase (IDPm), an enzyme involved in the reduction of NADP+ to… 
2002
2002
Cloning, Sequencing, and Expression of a Gene Encoding the Monomeric Isocitrate Dehydrogenase of the Nitrogen-fixing Bacterium, Azotobacter vinelandii
Isocitrate dehydrogenase (IDH: EC 1.1.1.42) of Azotobacter vinelandii was purified to an electrophoretically homogeneous state… 
1972
1972
A study of spontaneous mutation rates at ten loci detectable by starch gel electrophoresis in Drosophila melanogaster.
Spontaneous mutation rates at ten allozyme loci on chromosomes II and III of Drosophila melanogaster were studied. Over the three… 
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