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IDH2 wt Allele

Known as: IDH, IDP, ICD-M 
Human IDH2 wt allele is located in the vicinity of 15q26.1 and is approximately 18 kb in length. This allele, which encodes isocitrate dehydrogenase… 
National Institutes of Health

Related topics

Related topics

14 relations
15q26.1AstrocytomaGlioblastoma, IDH-MutantHomo sapiens

Broader (1)

IDH2 gene

Papers overview

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Highly Cited
2017
Highly Cited
2017
Mutant IDH1 regulates the tumor-associated immune system in gliomas
Amankulor et al. created a syngeneic pair mouse model for mutant IDH1 (muIDH1) and wild-type IDH1 (wtIDH1) gliomas and… 
Highly Cited
2015
Highly Cited
2015
CDKN2A Loss Is Associated With Shortened Overall Survival in Lower-Grade (World Health Organization Grades II–III) Astrocytomas
Abstract Lower-grade (World Health Organization Grades II and III) gliomas vary widely in clinical behavior and are classified as… 
Highly Cited
2014
Highly Cited
2014
Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH.
PURPOSE Patients with 1p/19q codeleted anaplastic oligodendroglial tumors who participated in RTOG (Radiation Therapy Oncology… 
Highly Cited
2014
Highly Cited
2014
Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes
Objective: To identify the prognostic significance of TERT promoter mutations (TERTp-mut) and their associations with common… 
Highly Cited
2013
Highly Cited
2013
Induction of sarcomas by mutant IDH2
Most chondrosarcoma patients exhibit gain-of-function mutations in either IDH1 or IDH2. Lu et al. found that IDH mutations were… 
Highly Cited
2010
Highly Cited
2010
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
PURPOSE To analyze the frequency and associations with prognostic markers and outcome of mutations in IDH genes encoding… 
Highly Cited
2010
Highly Cited
2010
Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations
Background We and other investigators previously reported that isolated nocturnal hypertension on ambulatory measurement (INH… 
Highly Cited
2010
Highly Cited
2010
LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
LNK mutation analysis was performed in 61 patients with blast-phase myeloproliferative neoplasms (MPN); post-primary… 
Highly Cited
2005
Highly Cited
2005
Predictors of New-Onset Diastolic and Systolic Hypertension: The Framingham Heart Study
Background—Factors leading differentially to the development of isolated diastolic (IDH), systolic-diastolic (SDH), and isolated… 
Highly Cited
2005
Highly Cited
2005
Regulation of Mitochondrial NADP+-dependent Isocitrate Dehydrogenase Activity by Glutathionylation*
Recently, we demonstrated that the control of mitochondrial redox balance and oxidative damage is one of the primary functions of… 
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