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IDH2 wt Allele

Known as: IDH, IDP, ICD-M 
Human IDH2 wt allele is located in the vicinity of 15q26.1 and is approximately 18 kb in length. This allele, which encodes isocitrate dehydrogenase… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Purpose: Lower-grade gliomas (WHO grade II/III) have been classified into clinically relevant molecular subtypes based on IDH and… Expand
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Highly Cited
2016
Highly Cited
2016
Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas. Mutant IDH… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND The prediction of clinical behavior, response to therapy, and outcome of infiltrative glioma is challenging. On the… Expand
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Highly Cited
2013
Highly Cited
2013
IDHology Among the most exciting drug targets to emerge from cancer genome sequencing projects are two related metabolic enzymes… Expand
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Highly Cited
2012
Highly Cited
2012
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… Expand
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Highly Cited
2010
Highly Cited
2010
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production… Expand
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Highly Cited
2010
Highly Cited
2010
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed… Expand
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