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Glioblastoma, IDH-Mutant

Known as: Secondary Glioblastoma, Secondary Glioblastoma Multiforme, Secondary Glioblastoma, IDH-Mutant 
A glioblastoma arising from a lower grade astrocytoma. It is more commonly seen in younger patients and is associated with IDH1 or IDH2 gene… 
National Institutes of Health

Related topics

Related topics

22 relations
AnaplasiaAstrocytesCentral Nervous SystemGrade four rank

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas
Background Epigenetic, genetic, and molecular studies have identified several diagnostic and prognostic markers in diffuse… 
Highly Cited
2012
Highly Cited
2012
Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy
2-Hydroxyglutarate, a metabolite overproduced in IDH-mutated gliomas, can be detected noninvasively in patients with brain tumors… 
Highly Cited
2009
Highly Cited
2009
Malignant Gliomas with Primitive Neuroectodermal Tumor‐like Components: A Clinicopathologic and Genetic Study of 53 Cases
Central nervous system neoplasms with combined features of malignant glioma and primitive neuroectodermal tumor (MG‐PNET) are… 
Highly Cited
2007
Highly Cited
2007
PIK3CA alterations in primary (de novo) and secondary glioblastomas
We assessed alterations in the EGFR/PTEN/PI3K pathway in 107 primary (de novo) glioblastomas and 32 secondary glioblastomas that… 
Highly Cited
2006
Highly Cited
2006
Primary Glioblastomas Express Mesenchymal Stem-Like Properties
Glioblastoma is the most common and aggressive primary brain cancer. Recent isolation and characterization of brain tumor… 
Highly Cited
2006
Highly Cited
2006
Different angiogenic phenotypes in primary and secondary glioblastomas
Primary and secondary glioblastomas (pGBM, sGBM) are supposed to evolve through different genetic pathways, including EGF… 
Highly Cited
2005
Highly Cited
2005
Amplification of genes encoding KIT, PDGFRα and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme
KIT, platelet‐derived growth factor receptors (PDGFRs) and vascular endothelial growth factor receptors (VEGFRs) are important… 
Highly Cited
2000
Highly Cited
2000
Loss of Heterozygosity on Chromosome 10 Is More Extensive in Primary (De Novo) Than in Secondary Glioblastomas
Glioblastomas develop de novo (primary glioblastomas) or through progression from low-grade or anaplastic astrocytoma (secondary… 
Highly Cited
2000
Highly Cited
2000
Loss of Heterozygosity on Chromosome 19 in Secondary Glioblastomas
Glioblastomas develop rapidly de novo (primary glioblastomas) or slowly through progression from low-grade or anaplastic… 
Highly Cited
1997
Highly Cited
1997
Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas
Abstract Primary glioblastomas develop rapidly de novo through a genetic pathway characterized by amplification/overexpression of… 
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