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Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons.
TLDR
Identification of key components of the HuC promoter has led to the establishment of a stable zebrafish transgenic line (HuC-GFP) in which GFP is expressed specifically in neurons. Expand
Cytosolic NADP+-dependent Isocitrate Dehydrogenase Plays a Key Role in Lipid Metabolism*
TLDR
It is reported here for the first time that IDPc plays a critical role in fat and cholesterol biosynthesis, and its enzyme activity and its protein content were increased in parallel in a time-dependent manner during differentiation of 3T3-L1 adipocytes. Expand
Zebrafish elav/HuC homologue as a very early neuronal marker
TLDR
Zebrafish elav/HuC homologue (zHuC) is isolated which has 89% homology to human HuC protein, which may be one of the earliest neuronal markers in zebrafish. Expand
Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos.
TLDR
This study characterized 3.4 kb 5'-regulatory sequence of a Notch target gene, her4, and used it to drive fluorescent gene expression in transgenic lines where the spatiotemporal pattern of Notch activation can be examined in vivo. Expand
Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish.
TLDR
It is suggested that a gradient of Fz8a-mediated Wnt8b signalling may play crucial role in patterning the posterior diencephalon and midbrain regions in the late gastrula. Expand
Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells.
TLDR
Direct evidence is provided correlating the activities of IDPc and the maintenance of the cellular redox state, suggesting that IDP c plays an important role in cellular defense against oxidative stress. Expand
Overexpression of a slit homologue impairs convergent extension of the mesoderm and causes cyclopia in embryonic zebrafish.
TLDR
Light is shed on a novel aspect of Slit function as a regulatory factor of mesodermal cell movement during gastrulation of zebrafish embryos. Expand
Regulation of the chondrocyte phenotype by β-catenin
TLDR
expression pattern of Jun, a known target gene of β -catenin, is essentially the same as that of β-Catenin both in vivo and in vitro suggesting that Jun and possibly activator protein 1 is involved in the β- catenin regulation of the chondrocyte phenotype. Expand
Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs.
TLDR
Observations support the inference that the evolutionary conserved gene, CD99L2, originated from a common ancestor gene of CD99, and its high conservation among species implies at least some essential function. Expand
Regulation of the chondrocyte phenotype by beta-catenin.
TLDR
expression pattern of Jun, a known target gene ofbeta-catenin, is essentially the same as that of beta-Catenin both in vivo and in vitro suggesting that Jun and possibly activator protein 1 is involved in the beta- catenin regulation of the chondrocyte phenotype. Expand
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