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IDH2 gene

Known as: ISOCITRATE DEHYDROGENASE, NADP(+)-SPECIFIC, MITOCHONDRIAL, IDPM, isocitrate dehydrogenase 2 (NADP+), mitochondrial 
This gene plays a role in intermediary metabolism.
National Institutes of Health

Related topics

Related topics

11 relations
AstrocytomaGlioblastoma, IDH-MutantIDH1 geneIDH2 Gene Mutation

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IDH2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Enasidenib (AG-221), a Potent Oral Inhibitor of Mutant Isocitrate Dehydrogenase 2 (IDH2) Enzyme, Induces Hematologic Responses in Patients with Myelodysplastic Syndromes (MDS)
Introduction : IDH2 mutations (m IDH2 ) are recurrent in ~5% of patients (pts) with MDS and ~15% of pts with acute myeloid… 
2013
2013
Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors
Oligodendroglial tumors (OTs) are primary brain tumors that show variable clinical and biological behavior. The 1p/19q codeletion… 
Highly Cited
2012
Highly Cited
2012
TET2, ASXL1, IDH1, IDH2, and c-CBL genes in JAK2- and MPL-negative myeloproliferative neoplasms
Mutations in the TET2 and ASXL1 genes have been described in approximately 14% and 8% of patients, respectively, with classic… 
2011
2011
Resveratrol protects left ventricle by increasing adenylate kinase and isocitrate dehydrogenase activities in rats with myocardial infarction.
Our prior study had shown that resveratrol was a potent cardioprotective agent in rats with myocardial infarction (MI). In this… 
2010
2010
IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders.
2005
2005
Cellular defense against heat shock-induced oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase
Heat shock may increase oxidative stress due to increased production of reactive oxygen species and/or the promotion of cellular… 
2001
2001
Subunit Interactions of Yeast NAD+-specific Isocitrate Dehydrogenase*
Yeast mitochondrial NAD+-specific isocitrate dehydrogenase is an octamer composed of four each of two nonidentical but related… 
Highly Cited
1993
Highly Cited
1993
Kinetic analysis of NAD(+)-isocitrate dehydrogenase with altered isocitrate binding sites: contribution of IDH1 and IDH2 subunits to regulation and catalysis.
NAD(+)-dependent isocitrate dehydrogenase from Saccharomyces cerevisiae is an allosterically regulated enzyme that exists as an… 
Highly Cited
1991
Highly Cited
1991
NAD(+)-dependent isocitrate dehydrogenase. Cloning, nucleotide sequence, and disruption of the IDH2 gene from Saccharomyces cerevisiae.
1983
1983
Gene mapping and linkage analysis in Chinese hamster: Assignment of the genes forAPRT, LDHA, IDH2, andGAA to chromosome 3
Interspecific somatic cell hybrids were generated by fusion of Chinese hamster spleen cells or primary fibroblasts with cells… 
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