IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders.

@article{Zou2010IDH1AI,
  title={IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders.},
  author={Yang Zou and Yun E. Zeng and Deng-Feng Zhang and Shan-hua Zou and Yun-feng Cheng and Yong-Gang Yao},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={402 2},
  pages={378-83}
}
Frequent mutations in the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) have been identified in gliomas and acute myeloid leukemia (AML). Our aim is to assess whether IDH mutations were presented in Chinese patients with various hematological disorders. In this study, we screened the IDH1 and IDH2 mutations in a cohort of 456 Chinese patients with various hematological malignancies and disorders. We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one… CONTINUE READING