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Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of the prominent roles is to regulate gene… Expand Intestinal microbes provide multicellular hosts with nutrients and confer resistance to infection. The delicate balance between… Expand We describe a new computer program, SnpEff, for rapidly categorizing the effects of variants in genome sequences. Once a genome… Expand RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA… Expand The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions… Expand Molecular networks guide the biochemistry of a living cell on multiple levels: Its metabolic and signaling pathways are shaped by… Expand Point mutations in the coding regions of genes are commonly assumed to exert their effects by altering single amino acids in the… Expand The green fluorescent protein (GFP) from the jellyfish Aequorea victoria is finding wide use as a genetic marker that can be… Expand Alignment of the 87 available sequences of group I self-splicing introns reveals numerous instances of covariation between… Expand Experiments were designed to test the effect of introns on gene expression in transgenic mice. Four different pairs of gene… Expand