Intermembranous space of mitochondrion

Mitochondrial Makeup Mapped Because mass spectrometry (MS) cannot be performed on living cells, biologists currently recover… Expand

Mitochondrial outer membrane permeabilization (MOMP) is often required for activation of the caspase proteases that cause… Expand

Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to… Expand

Mitochondria contain ∼1,000 different proteins, most of which are imported from the cytosol. Two import pathways that direct… Expand

In addition to the well-established role of the mitochondria in energy metabolism, regulation of cell death has recently emerged… Expand

Rhomboids, evolutionarily conserved integral membrane proteases, participate in crucial signaling pathways. Presenilin-associated… Expand

We describe here a pathway for the import of proteins into the intermembrane space (IMS) of mitochondria. Substrates of this… Expand

Mitochondria are central to many forms of cell death, usually via the release of pro-apoptotic proteins from the mitochondrial… Expand

Apoptosis inducing factor (AIF) is a novel apoptotic effector protein that induces chromatin condensation and large-scale… Expand

Representative samples of mitochondrial and chloroplast targeting peptides have been analyzed in terms of amino acid composition… Expand