Intermembranous space of mitochondrion

RNA import into mammalian mitochondria is considered essential for replication, transcription, and translation of the… (More)

Cytokines affect a variety of cellular functions, including regulation of cell numbers by suppression of programmed cell death… (More)

Autophagy is a catabolic membrane-trafficking process that occurs in all eukaryotic cells and leads to the hydrolytic degradation… (More)

We describe here a pathway for the import of proteins into the intermembrane space (IMS) of mitochondria. Substrates of this… (More)

Mitochondria import nuclear-encoded precursor proteins to four different subcompartments. Specific import machineries have been… (More)

Tom40 forms the central channel of the preprotein translocase of the mitochondrial outer membrane (TOM complex). The precursor of… (More)

Amyotrophic lateral sclerosis (ALS) is an age-dependent neurodegenerative disease that causes motor neuron degeneration… (More)

The yeast protein cytochrome c peroxidase (Ccp1) is nuclearly encoded and imported into the mitochondrial intermembrane space… (More)

Mutations in the dynamin-related GTPase, Mgm1p, have been shown to cause mitochondrial aggregation and mitochondrial DNA loss in… (More)

Tim8 and Tim13 are non-essential, conserved proteins of the mitochondrial intermembrane space, which are organized in a hetero… (More)