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- Influence
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
- E. Pebay-Peyroula, C. Dahout-Gonzalez, R. Kahn, V. Trézéguet, G. J. Lauquin, G. Brandolin
- Biology, Medicine
- Nature
- 6 November 2003
ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the… Expand
Relations between structure and function of the mitochondrial ADP/ATP carrier.
- H. Nury, C. Dahout-Gonzalez, V. Trézéguet, G. Lauquin, G. Brandolin, E. Pebay-Peyroula
- Biology, Medicine
- Annual review of biochemistry
- 6 June 2006
Import and export of metabolites through mitochondrial membranes are vital processes that are highly controlled and regulated at the level of the inner membrane. Proteins of the mitochondrial carrier… Expand
The mitochondrial ADP/ATP carrier: structural, physiological and pathological aspects.
- C. Fiore, V. Trézéguet, +7 authors P. Vignais
- Biology, Medicine
- Biochimie
- 1 February 1998
Under the conditions of oxidative phosphorylation, the mitochondrial ADP/ATP carrier catalyses the one to one exchange of cytosolic ADP against matrix ATP across the inner mitochondrial membrane. The… Expand
Structural basis for lipid‐mediated interactions between mitochondrial ADP/ATP carrier monomers
- H. Nury, C. Dahout-Gonzalez, V. Trézéguet, G. Lauquin, G. Brandolin, E. Pebay-Peyroula
- Chemistry, Medicine
- FEBS letters
- 7 November 2005
The oligomerization state of the ADP/ATP carrier is an important issue in understanding the mechanism underlying nucleotide exchange across the inner mitochondrial membrane. The first high resolution… Expand
Melibiose permease of Escherichia coli: large scale purification and evidence that H+, Na+, and Li+ sugar symport is catalyzed by a single polypeptide.
- T. Pourcher, S. Leclercq, G. Brandolin, G. Leblanc
- Chemistry, Medicine
- Biochemistry
- 4 April 1995
As much as 20-30 mg of functional recombinant melibiose permease (Mel-6His permease) of Escherichia coli, carrying a carboxy-terminal affinity tag for metallic ions (six successive histidines), can… Expand
A Phosphatidylserine-binding Site in the Cytosolic Fragment of Clostridium sordellii Lethal Toxin Facilitates Glucosylation of Membrane-bound Rac and Is Required for Cytotoxicity*
- B. Mesmin, Karine Robbe, +4 authors B. Antonny
- Biology, Medicine
- Journal of Biological Chemistry
- 26 November 2004
Large clostridial toxins glucosylate some small G proteins on a threonine residue, thereby preventing their interactions with effector molecules and regulators. We show that the glucosyltransferase… Expand
The anti-inflammatory agent flufenamic acid depresses store-operated channels by altering mitochondrial calcium homeostasis
- Peng Tu, G. Brandolin, A. Bouron
- Chemistry, Medicine
- Neuropharmacology
- 1 May 2009
Fenamates like flufenamic acid (FFA) are anti-inflammatory drugs known to alter ion fluxes through the plasma membrane. They are for instance potent blockers of cation and anion channels, and FFA is… Expand
Control of oxidative phosphorylation in rat heart mitochondria. The role of the adenine nucleotide carrier.
- J. Doussière, E. Ligeti, G. Brandolin, P. Vignais
- Biology, Medicine
- Biochimica et biophysica acta
- 31 August 1984
Inhibitor titration experiments carried out with carboxyatractyloside, oligomycin and rotenone show that in the case of heart mitochondria the membrane-bound ATPase and the respiratory chain are the… Expand
Effects of p47phox C Terminus Phosphorylations on Binding Interactions with p40phox and p67phox
- C. Massenet, Sylvie Chenavas, +4 authors F. Fieschi
- Chemistry, Medicine
- Journal of Biological Chemistry
- 8 April 2005
The neutrophil NADPH oxidase produces superoxide anions in response to infection. This reaction is activated by association of cytosolic factors, p47phox and p67phox, and a small G protein Rac with… Expand
Nucleotide exchange in mitochondria: insight at a molecular level.
- E. Pebay-Peyroula, G. Brandolin
- Biology, Medicine
- Current opinion in structural biology
- 1 August 2004
Mitochondrial carrier proteins are embedded in the inner mitochondrial membrane and ensure the transport of many important metabolites. The ADP/ATP carrier imports ADP into the mitochondrial matrix… Expand