• Publications
  • Influence
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in theExpand
  • 783
  • 72
  • PDF
Relations between structure and function of the mitochondrial ADP/ATP carrier.
Import and export of metabolites through mitochondrial membranes are vital processes that are highly controlled and regulated at the level of the inner membrane. Proteins of the mitochondrial carrierExpand
  • 147
  • 15
  • PDF
The mitochondrial ADP/ATP carrier: structural, physiological and pathological aspects.
Under the conditions of oxidative phosphorylation, the mitochondrial ADP/ATP carrier catalyses the one to one exchange of cytosolic ADP against matrix ATP across the inner mitochondrial membrane. TheExpand
  • 219
  • 11
Structural basis for lipid‐mediated interactions between mitochondrial ADP/ATP carrier monomers
The oligomerization state of the ADP/ATP carrier is an important issue in understanding the mechanism underlying nucleotide exchange across the inner mitochondrial membrane. The first high resolutionExpand
  • 161
  • 9
Melibiose permease of Escherichia coli: large scale purification and evidence that H+, Na+, and Li+ sugar symport is catalyzed by a single polypeptide.
As much as 20-30 mg of functional recombinant melibiose permease (Mel-6His permease) of Escherichia coli, carrying a carboxy-terminal affinity tag for metallic ions (six successive histidines), canExpand
  • 90
  • 6
A Phosphatidylserine-binding Site in the Cytosolic Fragment of Clostridium sordellii Lethal Toxin Facilitates Glucosylation of Membrane-bound Rac and Is Required for Cytotoxicity*
Large clostridial toxins glucosylate some small G proteins on a threonine residue, thereby preventing their interactions with effector molecules and regulators. We show that the glucosyltransferaseExpand
  • 47
  • 4
The anti-inflammatory agent flufenamic acid depresses store-operated channels by altering mitochondrial calcium homeostasis
Fenamates like flufenamic acid (FFA) are anti-inflammatory drugs known to alter ion fluxes through the plasma membrane. They are for instance potent blockers of cation and anion channels, and FFA isExpand
  • 19
  • 4
Control of oxidative phosphorylation in rat heart mitochondria. The role of the adenine nucleotide carrier.
Inhibitor titration experiments carried out with carboxyatractyloside, oligomycin and rotenone show that in the case of heart mitochondria the membrane-bound ATPase and the respiratory chain are theExpand
  • 67
  • 3
Effects of p47phox C Terminus Phosphorylations on Binding Interactions with p40phox and p67phox
The neutrophil NADPH oxidase produces superoxide anions in response to infection. This reaction is activated by association of cytosolic factors, p47phox and p67phox, and a small G protein Rac withExpand
  • 64
  • 3
Nucleotide exchange in mitochondria: insight at a molecular level.
Mitochondrial carrier proteins are embedded in the inner mitochondrial membrane and ensure the transport of many important metabolites. The ADP/ATP carrier imports ADP into the mitochondrial matrixExpand
  • 60
  • 3