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Prediction of chain flexibility in proteins
This work has analyzed 31 refined protein structures to develop a method for predicting flexible segments from a given amino acid sequence and found that segmental flexibility is more indicative of an antigenic determinant than the selection criteria mentioned above.
Structure of the outer membrane protein A transmembrane domain
The structure of the OmpA transmembrane domain consists of a regular, extended eight-stranded ß-barrel and appears to be constructed like an inverse micelle with large water-filled cavities, but does not form a pore.
Principles of Protein Structure
Structural Basis for the Entrance into the Phenylpropanoid Metabolism Catalyzed by Phenylalanine Ammonia-Lyase
The enzyme from parsley was crystallized, and the structure was elucidated at 1.7-Å resolution, and a pathway of the catalyzed reaction is proposed in agreement with established biochemical data.
The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence.
The structure of bacterial outer membrane proteins.
- G. Schulz
- BiologyBiochimica et Biophysica Acta
- 11 October 2002
The Structure of a Retinal-Forming Carotenoid Oxygenase
Enzymes that produce retinal and related apocarotenoids constitute a sequence- and thus structure-related family, a member of which was analyzed by x-ray diffraction. This member is an oxygenase and…
The Structure of a Mycobacterial Outer-Membrane Channel
An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel, the first structure of a mycobacterial outer-membrane protein.
Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 A resolution. A model for a catalytic transition state.
Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.
- A. Ruf, J. Mennissier de Murcia, G. de Murcia, G. Schulz
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 23 July 1996
The crystal structures of the catalytic fragment of chicken poly(ADP-ribose) polymerase with and without a nicotinamide-analogue inhibitor have been elucidated, because this enzyme is involved in the regulation of DNA repair, its inhibitors are of interest for cancer therapy.