Skip to search formSkip to main contentSkip to account menu

Interleukin-1

Known as: Interleukin 1, interleukin-1 (IL-1), Epidermal Cell Derived Thymocyte Activating Factor 
Interleukin-1 (endogenous pyrogen), produced primarily by monocytes, is an important pro-inflammatory cytokine that mediates the acute phase host… 
National Institutes of Health

Related topics

Related topics

39 relations
Caspase-1Cell Proliferation Regulatory ProcessCytokine GeneCytokine Receptor Binding

Broader (3)

Hematopoietic Cell Growth FactorsInterleukinscytokine

Narrower (7)

IL36A protein, humanIL37 protein, humanRecombinant Interleukin-1endogenous pyrogen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Proliferation of ramified microglia on an astrocyte monolayer: Characterization of stimulatory and inhibitory cytokines
Proliferation of ramified microglia is a common phenomenon in brain pathology, but little is known about how this is regulated… 
Review
1995
Review
1995
Does endotoxin stimulate cells by mimicking ceramide?
Highly Cited
1986
Highly Cited
1986
A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity.
Short peptide fragments of human and murine interleukin 1 (IL 1) were synthesized on the basis of their predicted exposure on the… 
Highly Cited
1985
Highly Cited
1985
Differential interleukin 1 elaboration by unfractionated and density fractionated human alveolar macrophages and blood monocytes: relationship to cell maturity.
The elaboration of interleukin 1 (IL 1) by mononuclear phagocytes is important in the regulation of human inflammatory and… 
Highly Cited
1984
Highly Cited
1984
The acute-phase response of cultured rat hepatocytes. System characterization and the effect of human cytokines.
Hepatocytes were isolated from adult livers and cultured for periods of up to 5 days as monolayers at an initial density of 10(6… 
Highly Cited
1983
Highly Cited
1983
Cyclosporin A inhibits lymphokine production but not the responses of macrophages to lymphokines.
Cyclosporin A (Cs A) exerted a dose-related inhibitory effect on antigen (ovalbumin, OVA) and phytohaemagglutinin (PHA)-induced… 
Highly Cited
1982
Highly Cited
1982
Lymphokines: their role in lymphocyte responses. Properties of interleukin 1.
Interleukin 1, or IL 1, otherwise known as lymphocyte-activating factor, is a macrophage-derived 12,000- to 15,000-dalton… 
Highly Cited
1981
Highly Cited
1981
The role of macrophages in the acute-phase response: SAA inducer is closely related to lymphocyte activating factor and endogenous pyrogen.
Highly Cited
1980
Highly Cited
1980
Macrophage heterogeneity in man. A subpopulation of HLA-DR-bearing macrophages required for antigen-induced T cell activation also contains stimulators for autologous-reactive T cells
Utilizing somatic cell hybridization, we have developed a monoclonal antibody that interacts only with cells of the monocyte… 
Highly Cited
1974
Highly Cited
1974
Potentiation of the T lymphocyte response to mitogens. III. Properties of the mediator(s) from adherent cells.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)