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Interleukin-1

Known as: Interleukin 1, interleukin-1 (IL-1), Epidermal Cell Derived Thymocyte Activating Factor 
Interleukin-1 (endogenous pyrogen), produced primarily by monocytes, is an important pro-inflammatory cytokine that mediates the acute phase host… 
National Institutes of Health

Related topics

Related topics

39 relations
Caspase-1Cell Proliferation Regulatory ProcessCytokine GeneCytokine Receptor Binding

Broader (3)

Hematopoietic Cell Growth FactorsInterleukinscytokine

Narrower (7)

IL36A protein, humanIL37 protein, humanRecombinant Interleukin-1endogenous pyrogen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
IL-17 is a T cell-derived, proinflammatory cytokine that is suspected to be involved in the development of various inflammatory… 
Highly Cited
1993
Highly Cited
1993
Interleukin 1 signaling occurs exclusively via the type I receptor.
Two receptors for the proinflammatory cytokine interleukin 1 (IL-1) have been cloned and characterized biochemically. While it… 
Highly Cited
1988
Highly Cited
1988
Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization
Interleukin-1 (IL-1), a protein produced by mononuclear phagocytes, helps to initiate the inflammatory response through its… 
Highly Cited
1988
Highly Cited
1988
A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.
Natural and synthetic immunomodulators that increase nonspecific resistance to infection induce interleukin 1 (IL-1) production… 
Highly Cited
1987
Highly Cited
1987
Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep.
The cytokines interleukin 1 (IL 1) and interferon (IFN) are immune response modifiers that are also pyrogenic and somnogenic… 
Highly Cited
1986
Highly Cited
1986
Prostaglandins as endogenous mediators of interleukin 1 production.
We examined the role of cyclooxygenase (CO)-derived metabolites of arachidonic acid (AA) in the regulation of interleukin 1 (IL 1… 
Highly Cited
1986
Highly Cited
1986
Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.
Granulocyte-macrophage colony-stimulating activity (GM-CSA) can be produced by a variety of normal cell types including… 
Highly Cited
1986
Highly Cited
1986
Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor
Human endothelial cells activated with IL-1 express a surface membrane- oriented procoagulant generating system characterized by… 
Highly Cited
1986
Highly Cited
1986
Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1.
We examined the effects of human interleukin 1 (IL-1) on the production of fibrinolytic components by cultured human vascular… 
Review
1985
Review
1985
Detection and characterization of high affinity plasma membrane receptors for human interleukin 1
Interleukin 1 (IL-1) is a polypeptide hormone that acts as a central mediator of inflammation. Since IL-1 action is presumably… 
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