Interleukin-1

Known as: Interleukin 1, interleukin-1 (IL-1), Epidermal Cell Derived Thymocyte Activating Factor 
Interleukin-1 (endogenous pyrogen), produced primarily by monocytes, is an important pro-inflammatory cytokine that mediates the acute phase host… (More)

Topic mentions per year

Topic mentions per year

1971-2017
0500100019712017

Papers overview

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Highly Cited
2009
Highly Cited
2009
Th17 cells, CD4(+) T cells that secrete interleukin-17 (IL-17), are pathogenic in autoimmune diseases and their development and… (More)
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Highly Cited
2009
Highly Cited
2009
T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes… (More)
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Highly Cited
2005
Highly Cited
2005
Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune… (More)
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Highly Cited
1999
Highly Cited
1999
Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor… (More)
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Highly Cited
1996
Highly Cited
1996
Many cytokines signal through different cell-surface receptors to activate the transcription factor NF-kappaB. Members of the… (More)
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Highly Cited
1995
Highly Cited
1995
The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-1 beta precursor to the proinflammatory… (More)
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Highly Cited
1995
Highly Cited
1995
A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature… (More)
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Highly Cited
1993
Highly Cited
1993
We have cloned the C. elegans cell death gene ced-3. A ced-3 transcript is most abundant during embryogenesis, the stage during… (More)
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Highly Cited
1992
Highly Cited
1992
Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of… (More)
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