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International union of pharmacology. XXII. Nomenclature for chemokine receptors.
A widely accepted receptor nomenclature system is described, ratified by the International Union of Pharmacology, that is facilitating clear communication in this area and updating current concepts of the biology and pharmacology of the chemokine system.
Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes,…
The results suggest that, in addition to its microbicidal activity, LL-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1.
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory…
Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells1
- Xin Chen, Monika Bäumel, D. Männel, O. Howard, J. Oppenheim
- BiologyThe Journal of Immunology
- 1 July 2007
It is demonstrated in this study that, in both resting and activated states, mouse peripheral CD4+CD25+ T regulatory cells (Tregs) expressed remarkably higher surface levels of TNFR2 than CD4-CD25− T effector cells (Teffs), suggesting that the slower response of Tregs than Teffs to TNF results in delayed immunosuppressive feedback effects.
Properties of the novel proinflammatory supergene "intercrine" cytokine family.
This review has summarized and discussed the available information concerning the regulation and structure of the genes, the structure and biochemical properties of the polypeptide products, their receptors, signal transduction, cell sources, and in vitro as well as in vivo activities of these cytokines.
Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.
- De Yang, A. Biragyn, D. Hoover, J. Lubkowski, J. Oppenheim
- BiologyAnnual review of immunology
- 19 March 2004
It appears that mammalian antimicrobial proteins contribute to both innate and adaptive antimicrobial immunity, as several defensins have considerable immunoenhancing activity.
Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells1
- Xin Chen, J. Subleski, Heather Kopf, O. Howard, D. Männel, J. Oppenheim
- Biology, MedicineThe Journal of Immunology
- 15 May 2008
TNFR2 is predominantly expressed by a subset of human and mouse CD4+CD25+FoxP3+ T regulatory cells (Tregs). In this study, we characterized the phenotype and function of TNFR2+ Tregs in peripheral…
Pleiotropic roles of formyl peptide receptors.
Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.
- T. Yoshimura, K. Matsushima, E. Leonard
- BiologyProceedings of the National Academy of Sciences…
- 1 December 1987
Another proinflammatory protein is purified that is chemotactic for human neutrophils from conditioned medium of lipopolysaccharide-stimulated monocytes and has up to 56% sequence similarity with several proteins that may be involved in host responses to infection or tissue injury.
A Seven-transmembrane, G Protein–coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells
It is demonstrated that SAA selectively induced Ca2+ mobilization and migration of HEK cells expressing FPRL1, a human seven-transmembrane domain phagocyte receptor with low affinity for fMLP, and high affinity for lipoxin A4, the first chemotactic ligand identified for F PRL1.