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Immunoglobulin Gene Rearrangement

Known as: Immunoglobulin gene rearrangements 
Any process of gene rearrangement that creates a novel junction among the immunoglobuling-coding variable, diversity, joining or constant segments… Expand
National Institutes of Health

Related topics

Related topics

5 relations
Cell Differentiation processImmune System ProcessesUNG geneUNG wt Allele
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Papers overview

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Highly Cited
2001
Highly Cited
2001
bcl‐2 and immunoglobulin gene rearrangement in patients with hepatitis C virus infection
An association between chronic hepatitis C virus (HCV) infection and clonal proliferation of B cells, including B cell lymphoma… Expand
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Highly Cited
2001
Highly Cited
2001
The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection.
The mechanism of lymphomagenesis of hepatitis C virus (HCV)-related B-cell lymphoma is unknown. Recently, it has been suggested… Expand
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Highly Cited
1996
Highly Cited
1996
Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene.
During B lymphocyte development, pro-B cells that fail to rearrange an immunoglobulin heavy (IgH) chain allele productively are… Expand
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Highly Cited
1995
Highly Cited
1995
Light chain replacement: a new model for antibody gene rearrangement
A functional B cell antigen receptor is thought to regulate antibody gene rearrangement either by stopping further rearrangement… Expand
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Highly Cited
1993
Highly Cited
1993
Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus.
B lymphocyte differentiation is characterized by an ordered series of Ig gene assembly and expression events. In the majority of… Expand
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Highly Cited
1993
Highly Cited
1993
The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages.
X-linked agammaglobulinemia (XLA) is an immunodeficiency disease in man, resulting from an arrest in early B cell differentiation… Expand
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Highly Cited
1984
Highly Cited
1984
Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma.
We describe the use of the Southern blot hybridization technique to diagnose B-cell lymphoma by detecting clonal immunoglobulin… Expand
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Highly Cited
1984
Highly Cited
1984
Heavy chain immunoglobulin gene rearrangement in acute nonlymphocytic leukemia.
Samples of leukemic cell DNA from 14 children with acute nonlymphocytic leukemia (ANLL) and 4 human myeloid leukemia cell lines… Expand
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Highly Cited
1983
Highly Cited
1983
Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.
We have explored the relationship among immunoglobulin gene rearrangement, cytoplasmic immunoglobulin production, and cell… Expand
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1983
1983
Immunoglobulin gene rearrangement during pre-B cell differentiation.
The experiments reported here were designed to answer two questions: (1) At what stage in normal pre-B cell development do… Expand
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