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B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals
Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-livedExpand
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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Bone resorption and remodeling is an intricately controlled, physiological process that requires the function of osteoclasts. The processes governing both the differentiation and activation ofExpand
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Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.
PU.1 is a member of the ets family of transcription factors and is expressed exclusively in cells of the hematopoietic lineage. Mice homozygous for a disruption in the PU.1 DNA binding domain areExpand
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Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4
T CELLS express T-cell antigen receptors (TCR) for the recognition of antigen in conjunction with the products of the major histocompatibility complex1,2. They also express two key surfaceExpand
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Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis
We report here the molecular cloning of a newly identified preprotachykinin gene, Pptc, which specifies the sequence for a new preprotachykinin protein and bioactive peptide designated hemokinin 1Expand
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Profound block in thymocyte development in mice lacking p56lck
THE protein Lck (p56lck) has a relative molecular mass of 56,000 and belongs to the Src family of tyrosine kinases1–3. It is expressed exclusively in lymphoid cells, predominantly in thymocytes andExpand
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CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity.
CD44 is expressed in various isoforms on numerous cell types and tissues during embryogenesis and in the mature organism. CD44 may also be involved in tumor growth. To study the multiple roles ofExpand
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Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice
The adaptor protein Lnk, and the closely related proteins APS and SH2B, form a subfamily of SH2 domain-containing proteins implicated in growth factor, cytokine, and immunoreceptor signaling. ToExpand
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Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity
Caspases are important for apoptosis but are also involved in mammalian cell survival and cell division. Here we report that caspase-3 is a negative regulator of B cell cycling. Mice deficient inExpand
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Bipotential precursors of B cells and macrophages in murine fetal liver
LYMPHOCYTES(B and T cells) derive continuously from the same multipotential stem cells that produce myeloid cells, including erythrocytes, granulocytes and macrophages1,2. Tri- and bipotentialExpand
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