Skip to search formSkip to main contentSkip to account menu

ITIM

Known as: Immunoreceptor Tyrosine-Based Inhibitory Motif 
ITIM (immunoreceptor Tyr-based inhibition motif) (I/V-X-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain in SHP1 and SHP2, e.g., in… 
National Institutes of Health

Related topics

Related topics

13 relations
CD22 protein, humanCD33 protein, humanErythropoietin ReceptorFCRL1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Co-aggregation of FcγRII with FcϵRI on Human Mast Cells Inhibits Antigen-induced Secretion and Involves SHIP-Grb2-Dok Complexes*
Signaling through the high affinity IgE receptor FcϵRI on human basophils and rodent mast cells is decreased by co-aggregating… 
2002
2002
Characterization of a Novel Killer Cell Lectin-Like Receptor (KLRH1) Expressed by Alloreactive Rat NK Cells1
NK cells have the ability to recognize and kill MHC-mismatched hemopoietic cells. In the present study, strain-specific… 
Highly Cited
2001
Highly Cited
2001
Integrin Activation by Regulated Dimerization and Oligomerization of Platelet Endothelial Cell Adhesion Molecule (Pecam)-1 from within the Cell
Platelet endothelial cell adhesion molecule (PECAM)-1 is a 130-kD transmembrane glycoprotein having six Ig homology domains… 
Highly Cited
1999
Highly Cited
1999
Induction of DAP12 phosphorylation, calcium mobilization, and cytokine secretion by Ly49H
The ability of several Ly49 family members to inhibit natural killer (NK) cell functions through recruitment of SHP‐1 phosphatase… 
Highly Cited
1999
Highly Cited
1999
Cloning and characterization of a novel activating Ly49 closely related to Ly49A.
The majority of the known Ly49 family members have been isolated from either C57BL/6 (B6) or BALB/c mice. Interestingly, the anti… 
Highly Cited
1999
Highly Cited
1999
Differential roles of N- and C-terminal immunoreceptor tyrosine-based inhibition motifs during inhibition of cell activation by killer cell inhibitory receptors.
Killer cell inhibitory receptors (KIRs) inhibit NK and T cell cytotoxicity when recognizing MHC class I molecules on target cells… 
Highly Cited
1998
Highly Cited
1998
Inhibitory and stimulatory functions of paired Ig-like receptor (PIR) family in RBL-2H3 cells.
In this study, we demonstrate potent regulatory function of the murine killer cell inhibitory receptor-like molecules, paired Ig… 
Highly Cited
1996
Highly Cited
1996
Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation.
Highly Cited
1996
Highly Cited
1996
The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling.
1996
1996
The Ly-49 D Receptor Activates Murine Natural Killer Cells
  • 1996
  • Corpus ID: 20105034
Proteins encoded by members of the Ly-49 gene family are predominantly expressed on murine natural killer (NK) cells. Several… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)