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ITIM

Known as: Immunoreceptor Tyrosine-Based Inhibitory Motif 
ITIM (immunoreceptor Tyr-based inhibition motif) (I/V-X-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain in SHP1 and SHP2, e.g., in… 
National Institutes of Health

Related topics

Related topics

13 relations
CD22 protein, humanCD33 protein, humanErythropoietin ReceptorFCRL1 protein, human

Papers overview

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2006
2006
Occupation of αvβ3-integrin by endogenous ligands modulates IGF-I receptor activation and proliferation of human intestinal smooth muscle
We have previously shown that endogenous IGF-I regulates growth of human intestinal smooth muscle cells by stimulating… 
2002
2002
Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1‐A1c)
We have exploited strain‐specific differences in the NK allorecognition repertoires to generate rat monoclonal antibodies against… 
Highly Cited
2000
Highly Cited
2000
Mutational Analysis Reveals Multiple Distinct Sites Within Fcγ Receptor IIB That Function in Inhibitory Signaling1
The low-affinity receptor for IgG, FcγRIIB, functions broadly in the immune system, blocking mast cell degranulation, dampening… 
Highly Cited
1999
Highly Cited
1999
Induction of DAP12 phosphorylation, calcium mobilization, and cytokine secretion by Ly49H
The ability of several Ly49 family members to inhibit natural killer (NK) cell functions through recruitment of SHP‐1 phosphatase… 
Highly Cited
1999
Highly Cited
1999
Differential roles of N- and C-terminal immunoreceptor tyrosine-based inhibition motifs during inhibition of cell activation by killer cell inhibitory receptors.
Killer cell inhibitory receptors (KIRs) inhibit NK and T cell cytotoxicity when recognizing MHC class I molecules on target cells… 
Highly Cited
1998
Highly Cited
1998
Genomic structures and chromosomal location of p91, a novel murine regulatory receptor family.
Recently, we found a novel murine cell-surface glycoprotein, designated as p91, expressed mainly in myeloid cells such as… 
1997
1997
Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell.
Highly Cited
1996
Highly Cited
1996
The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling.
1996
1996
The Ly-49 D Receptor Activates Murine Natural Killer Cells
  • 1996
  • Corpus ID: 20105034
Proteins encoded by members of the Ly-49 gene family are predominantly expressed on murine natural killer (NK) cells. Several… 
1996
1996
Integration of activatory and inhibitory signals in human B-cells.
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