ITIM

Known as: Immunoreceptor Tyrosine-Based Inhibitory Motif 
ITIM (immunoreceptor Tyr-based inhibition motif) (I/V-X-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain in SHP1 and SHP2, e.g., in… (More)
National Institutes of Health

Papers overview

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Review
2008
Review
2008
Receptors carrying immunoreceptor tyrosine-based inhibition motifs (ITIMs) in their cytoplasmic tail control a vast array of… (More)
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Review
2006
Review
2006
Paradigms of protein tyrosine kinase (PTK)-mediated immunoreceptor signalling have developed largely from studies of molecules… (More)
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Highly Cited
2004
Highly Cited
2004
To study the cis- and trans-acting factors that mediate programmed death 1 (PD-1) signaling in primary human CD4 T cells, we… (More)
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Highly Cited
2003
Highly Cited
2003
Programmed death-1 ligand (PD-L)1 and PD-L2 are ligands for programmed death-1 (PD-1), a member of the CD28/CTLA4 family… (More)
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Highly Cited
2002
Highly Cited
2002
Programmed death-1 (PD-1) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor expressed upon T cell… (More)
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Highly Cited
1999
Highly Cited
1999
PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-based inhibitory motif, is induced in lymphocytes and… (More)
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Review
1998
Review
1998
NK cells are regulated by opposing signals from receptors that activate and inhibit effector function. While positive stimulation… (More)
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Highly Cited
1998
Highly Cited
1998
Natural killer (NK) cells express cell-surface receptors of the immunoglobulin and C-type lectin superfamilies that recognize… (More)
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Review
1997
Review
1997
A diverse group of inhibitory receptors, including FcgammaRII, killer cell inhibitory receptors, and B22, shares an… (More)
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Highly Cited
1996
Highly Cited
1996
CD94 receptors expressed on NK cells have been implicated in the recognition of certain HLA class I allotypes. We now demonstrate… (More)
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