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ITIM

Known as: Immunoreceptor Tyrosine-Based Inhibitory Motif 
ITIM (immunoreceptor Tyr-based inhibition motif) (I/V-X-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain in SHP1 and SHP2, e.g., in… 
National Institutes of Health

Related topics

Related topics

13 relations
CD22 protein, humanCD33 protein, humanErythropoietin ReceptorFCRL1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8+ T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Purpose: T-cell immunoglobulin and immunoreceptor tyrosine–based inhibitory motif (ITIM) domain (TIGIT) is a recently identified… 
Review
2015
Review
2015
Immune checkpoint blockade in hematologic malignancies.
Therapeutic blockade of immune checkpoint pathways, in particular cytotoxic T-lymphocyte associated protein 4 and programmed… 
Highly Cited
2007
Highly Cited
2007
A Comprehensive Proteomics and Genomics Analysis Reveals Novel Transmembrane Proteins in Human Platelets and Mouse Megakaryocytes Including G6b-B, a Novel Immunoreceptor Tyrosine-based Inhibitory…
The platelet surface is poorly characterized due to the low abundance of many membrane proteins and the lack of specialist tools… 
Review
2006
Review
2006
You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling
Paradigms of protein tyrosine kinase (PTK)‐mediated immunoreceptor signalling have developed largely from studies of molecules… 
Highly Cited
2004
Highly Cited
2004
SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation1
To study the cis- and trans-acting factors that mediate programmed death 1 (PD-1) signaling in primary human CD4 T cells, we… 
Highly Cited
2000
Highly Cited
2000
Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice
PD-1 is an immunoglobulin superfamily member bearing an immunoreceptor tyrosine-based inhibitory motif, and disruption of the PD… 
Highly Cited
1999
Highly Cited
1999
APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif.
We have identified a novel member of the calcium-dependent (C-type) lectin family. This molecule, designated DCIR (for dendritic… 
Highly Cited
1997
Highly Cited
1997
A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.
Leukocyte Ig-like receptors (LIRs) are a newly discovered family of immunoreceptors expressed on monocytes and B cells and at… 
Highly Cited
1997
Highly Cited
1997
Regulation through inhibitory receptors: Lessons from natural killer cells.
Highly Cited
1996
Highly Cited
1996
Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.
CD94 receptors expressed on NK cells have been implicated in the recognition of certain HLA class I allotypes. We now demonstrate… 
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