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T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.
This study shows that there is cross-talk between the tumour necrosis factor and IFN families of cytokines, through which IFN-gamma provides a negative link between T-cell activation and bone resorption and may offer a therapeutic approach to treat the inflammation-induced tissue breakdown.
Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model
Gene therapy employing MSCs as a targeting vehicle for gene therapy of malignant brain neoplasms would be promising as a new therapeutic approach for refractory brain tumor.
The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells.
Redox regulation of cellular activation.
Adult T cell leukemia-derived factor (ADF), which was originally defined as an IL-2 receptor alpha-chain/Tac inducer produced by human T cell lymphotrophic virus-I (HTLV-I)-transformed T cells, has been identified as human TRX.
Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis.
RANKL/ODF expressed on synovial fibroblasts is involved in rheumatoid bone destruction by inducing osteoclastogenesis and would therefore be a good therapeutic target.
Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system
- K. Nakamura, T. Kaneko, Y. Yamashita, H. Hasegawa, H. Katoh, M. Negishi
- BiologyThe Journal of comparative neurology
- 12 June 2000
The characteristic distribution of EP3R provides valuable information on the mechanisms for various physiologic actions of prostaglandin E2 in the central and peripheral nervous systems and suggests thatEP3R plays regulatory roles in the noradrenergic and serotonergic monoamine systems.
L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.
It is suggested that L-152,804 is a selective and potent non-peptide Y5 antagonist with oral bioavailability and brain penetrability and represents a useful tool to address the physiological role of the Y5 receptor.
Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell-cell contact sites
Results indicate that direct interaction of growth factors and cell adhesion molecules may control cell proliferation during the cell-cell adhesion process.
Connection Between B Lymphocyte and Osteoclast Differentiation Pathways1
It is demonstrated that B-lymphoid lineage cells are a major source of endogenous ODF/RANKL in bone marrow and support osteoclast differentiation in vitro and may affect the pathophysiology of bone disorders through regulating osteOClastogenesis.
Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells.
- K. Nakamura, H. Yano, H. Uchida, S. Hashimoto, E. Schaefer, H. Sabe
- BiologyThe Journal of biological chemistry
- 1 September 2000
It is found that tyrosine phosphorylation of paxillin was a prominent event upon integrin activation during epithelial-mesenchymal trans-differentiation and cell migration, and is involved in the temporospatial regulation of focal adhesion formation and actin cytoskeletal organization in motile cells.