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T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.
TLDR
This study shows that there is cross-talk between the tumour necrosis factor and IFN families of cytokines, through which IFN-gamma provides a negative link between T-cell activation and bone resorption and may offer a therapeutic approach to treat the inflammation-induced tissue breakdown. Expand
The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells.
TLDR
It is shown here that FcgammaRIIB-BCR coaggregation leads to increased tyrosine phosphorylation of the RasGAP-binding protein p62dok, with a concomitant increase in its binding to RasG AP. Expand
Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model
TLDR
Gene therapy employing MSCs as a targeting vehicle for gene therapy of malignant brain neoplasms would be promising as a new therapeutic approach for refractory brain tumor. Expand
Redox regulation of cellular activation.
TLDR
Adult T cell leukemia-derived factor (ADF), which was originally defined as an IL-2 receptor alpha-chain/Tac inducer produced by human T cell lymphotrophic virus-I (HTLV-I)-transformed T cells, has been identified as human TRX. Expand
Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis.
TLDR
RANKL/ODF expressed on synovial fibroblasts is involved in rheumatoid bone destruction by inducing osteoclastogenesis and would therefore be a good therapeutic target. Expand
Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system
TLDR
The characteristic distribution of EP3R provides valuable information on the mechanisms for various physiologic actions of prostaglandin E2 in the central and peripheral nervous systems and suggests thatEP3R plays regulatory roles in the noradrenergic and serotonergic monoamine systems. Expand
Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell-cell contact sites
TLDR
Results indicate that direct interaction of growth factors and cell adhesion molecules may control cell proliferation during the cell-cell adhesion process. Expand
Connection Between B Lymphocyte and Osteoclast Differentiation Pathways1
TLDR
It is demonstrated that B-lymphoid lineage cells are a major source of endogenous ODF/RANKL in bone marrow and support osteoclast differentiation in vitro and may affect the pathophysiology of bone disorders through regulating osteOClastogenesis. Expand
L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.
TLDR
It is suggested that L-152,804 is a selective and potent non-peptide Y5 antagonist with oral bioavailability and brain penetrability and represents a useful tool to address the physiological role of the Y5 receptor. Expand
Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions.
TLDR
Observations indicate that TARC and MDC actively participate in the pathogenesis of AD-like lesions in NC/Nga mice and that these Th2 chemokines could be novel targets for intervention therapy of AD in humans. Expand
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