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Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection.
TREM and TREM-like receptors in inflammation and disease.
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
- H. Mizoguchi, J. O’Shea, D. Longo, C. Loeffler, D. McVicar, A. Ochoa
- Biology, MedicineScience
- 11 December 1992
In an in vivo murine colon carcinoma model (MCA-38), animals bearing a tumor longer than 26 days develop CD8+ T cells with impaired cytotoxic function, decreased expression of the tumor necrosis factor-alpha and granzyme B genes, and decreased ability to mediate an antitumor response in vivo.
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Together deletion in mice of two Tec kinases caused marked defects in TCR responses including proliferation, cytokine production, and apoptosis in vitro and adaptive immune responses to Toxoplasma gondii in vivo, establishing Tec kinase as critical regulators of TCR signaling required for phospholipase C-gamma activation.
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL- 12
- C. Bacon, D. McVicar, J. Ortaldo, R. Rees, J. O’Shea, J. Johnston
- BiologyThe Journal of experimental medicine
- 1 January 1995
It is shown that IL- 12 and IL-2 induce tyrosine phosphorylation of distinct members of the Janus (JAK) family of protein tyrosin kinases in human T lymphocytes.
The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense.
- A. Bashirova, Maureen P. Martin, D. McVicar, M. Carrington
- BiologyAnnual review of genomics and human genetics
- 1 September 2006
The polymorphism of the KIR locus parallels that of the MHC, facilitating the adaptation of the immune system to a dynamic, challenging environment.
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2
It is reported that a new member of the Janus family of kinases (Jak-3) is coupled to the IL-2R in human peripheral blood T cells and natural killer cells.
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.
Gamma c mutations in at least some XSCID and XCID patients prevent normal Jak3 activation, suggesting that mutations of Jak3 may result in an XSCIDs-like phenotype.
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
It is shown that dysregulation of lipid metabolism in NAFLD causes a selective loss of intrahepatic CD4+ but not CD8+ T lymphocytes, leading to accelerated hepatocarcinogenesis, providing an unexpected link between lipid dysregulation and impaired anti-tumour surveillance.
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C
These data strongly implicate high HLA-C expression levels in more effective control of HIV-1, potentially through better antigen presentation to cytotoxic T lymphocytes or recognition and killing of infected cells by natural killer cells.