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Sequence and organization of the human mitochondrial genome
The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome.
DAP12-mediated Signal Transduction in Natural Killer Cells
The data demonstrate the dependence of DAP12-coupled receptors on Syk and suggest that the outcome of Ly49D/DAP12 engagement will be regulated by Cbl and culminate in the activation of transcription factors.
Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2)
- L. Mason, J. Ortaldo, H. Young, V. Kumar, M. Bennett, S. Anderson
- BiologyThe Journal of experimental medicine
- 1 August 1995
The molecular cloning of the LGL-1 cDNA from a severe combined immunodeficient-adherent lymphokine-activated killer cell library transfected into Cos-7 cells is found to be homologous to the Ly- 49 gene at both the nucleotide (85%) and amino acid levels (73%).
Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells.
On the basis of the labeling patterns obtained with UEA and TPA and the reported specificities of these two lectins, it is suggested that the majority of the fucose detected is associated with type 1 carbohydrate chains.
CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.
It is shown that most CD8 T cells possess a restricted KIR expression pattern, often dominated by a single activating or inhibitory KIR, and that the expression of KIR was independent of expression of self-HLA class I ligands.
Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome
The Ly49 gene cluster of NOD mice is a unique mix of elements seen in previously characterized Ly49 haplotypes resulting in a disproportionately large number of functional activating Ly49 genes that were confirmed in cytotoxicity assays.
Identification of probabilistic transcriptional switches in the Ly49 gene cluster: a eukaryotic mechanism for selective gene activation.
Class I MHC-Binding Characteristics of the 129/J Ly49 Repertoire1
- A. Makrigiannis, Amanda T. Pau, A. Saleh, R. Winkler-Pickett, J. Ortaldo, S. Anderson
- BiologyThe Journal of Immunology
- 15 April 2001
This study shows that the Ly49 repertoire and its MHC-binding characteristics can be very different among inbred mouse strains, and should be considered when using 129-derived embryonic stem cells for the production of gene-targeted mice.
Cloning and characterization of a novel activating Ly49 closely related to Ly49A.
Ly49P, therefore, represents a novel member of the Ly49 activating receptor subfamily, and Ab-mediated cross-linking of Ly49P resulted in mouse DAP12 phosphorylation and Ca2+ mobilization, indicating that Ly 49P is a competent activation receptor.