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Sequence and organization of the human mitochondrial genome
TLDR
The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs. Expand
Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome.
TLDR
The bovine 12 S and 16 S Ribosomal RNA genes, when compared with those from human mitochondrial DNA, show conserved features that are consistent with proposed secondary structure models for the ribosomal RNAs. Expand
Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2)
TLDR
The molecular cloning of the LGL-1 cDNA from a severe combined immunodeficient-adherent lymphokine-activated killer cell library transfected into Cos-7 cells is found to be homologous to the Ly- 49 gene at both the nucleotide (85%) and amino acid levels (73%). Expand
Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells.
TLDR
On the basis of the labeling patterns obtained with UEA and TPA and the reported specificities of these two lectins, it is suggested that the majority of the fucose detected is associated with type 1 carbohydrate chains. Expand
Cloning and characterization of a novel activating Ly49 closely related to Ly49A.
TLDR
Ly49P, therefore, represents a novel member of the Ly49 activating receptor subfamily, and Ab-mediated cross-linking of Ly49P resulted in mouse DAP12 phosphorylation and Ca2+ mobilization, indicating that Ly 49P is a competent activation receptor. Expand
Identification of probabilistic transcriptional switches in the Ly49 gene cluster: a eukaryotic mechanism for selective gene activation.
TLDR
A pair of overlapping, divergent promoters discovered in the Ly49g gene functions as a molecular switch that can produce a forward transcript containing the coding region of the gene or a noncoding transcript in the opposite direction, supporting a promoter competition model of selective gene activation. Expand
Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome
TLDR
The Ly49 gene cluster of NOD mice is a unique mix of elements seen in previously characterized Ly49 haplotypes resulting in a disproportionately large number of functional activating Ly49 genes that were confirmed in cytotoxicity assays. Expand
Identification of a Novel Ly49 Promoter That Is Active in Bone Marrow and Fetal Thymus1
TLDR
The current study reveals the presence of an additional Ly49 promoter (Pro-1) and two noncoding exons upstream of the previously defined promoter ( pro-2) that is not active in mature NK cells, suggesting that Pro-1 represents an early Ly 49 promoter. Expand
CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.
TLDR
It is shown that most CD8 T cells possess a restricted KIR expression pattern, often dominated by a single activating or inhibitory KIR, and that the expression of KIR was independent of expression of self-HLA class I ligands. Expand
Synthesis of the small subunit of ribulose-bisphosphate carboxylase from genes cloned into plasmids containing the SP6 promoter.
TLDR
DNA sequences encoding ribulose 1,5-bisphosphate carboxylase small subunit precursor from Pisum sativum L. have been transcribed from plasmids containing the SP6 promoter, and translated in a wheat germ cell-free system to establish the crucial role of the transit peptide in protein import into the chloroplast. Expand
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