IRGM gene

Known as: IRGM1, LRG47, INTERFERON-INDUCIBLE PROTEIN 1, MOUSE, HOMOLOG OF 
This gene is involved in inflammation.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans… (More)
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2015
2015
IRGM, encoded by a uniquely human gene conferring risk for inflammatory diseases, affects autophagy through an unknown mechanism… (More)
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Highly Cited
2011
Highly Cited
2011
Susceptibility to Crohn's disease, a complex inflammatory disease, is influenced by common variants at many loci. The common… (More)
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Highly Cited
2011
Highly Cited
2011
Autophagy is a conserved degradative pathway used as a host defense mechanism against intracellular pathogens. However, several… (More)
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Highly Cited
2010
Highly Cited
2010
IRGM, a human immunity-related GTPase, confers autophagic defence against intracellular pathogens by an unknown mechanism. Here… (More)
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Highly Cited
2009
Highly Cited
2009
The human immunity-related GTPase M (IRGM) has been shown to be critically involved in regulating autophagy as a means of… (More)
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Highly Cited
2009
Highly Cited
2009
Immunity-related GTPases (IRG) play an important role in defense against intracellular pathogens. One member of this gene family… (More)
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Highly Cited
2008
Highly Cited
2008
Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic… (More)
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Highly Cited
2008
Highly Cited
2008
Genome-wide association studies have identified PHOX2B, FAM92B, IRGM and NCF4 as candidate susceptibility factors for ileal Crohn… (More)
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Highly Cited
2007
Highly Cited
2007
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong… (More)
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