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IRGM gene

Known as: IRGM1, LRG47, INTERFERON-INDUCIBLE PROTEIN 1, MOUSE, HOMOLOG OF 
This gene is involved in inflammation.
National Institutes of Health

Related topics

Related topics

6 relations
AutophagyHydrolysisImmunityImmunity-Related GTPase Family M Protein

Broader (1)

Genes

Narrower (1)

IRGM wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy
Highly Cited
2013
Highly Cited
2013
IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins
Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance… 
Review
2012
Review
2012
IFN-inducible GTPases in host cell defense.
Review
2012
Review
2012
Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors.
Review
2011
Review
2011
Insect-resistant genetically modified rice in China: from research to commercialization.
From the first insect-resistant genetically modified (IRGM) rice transformation in 1989 in China to October 2009 when the Chinese… 
Review
2011
Review
2011
Innate immunity in the small intestine
Purpose of review This article reviews the most recent publications on innate immunity in the small intestine. We will go over… 
Highly Cited
2010
Highly Cited
2010
Human IRGM Regulates Autophagy and Its Cell-Autonomous Immunity Functions Through Mitochondria
IRGM, a human immunity-related GTPase, confers autophagic defence against intracellular pathogens by an unknown mechanism. Here… 
Highly Cited
2010
Highly Cited
2010
Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease
DNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase related family, M (IRGM) and… 
Highly Cited
2006
Highly Cited
2006
Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria
Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the… 
Review
2003
Review
2003
The genetics of inflammatory bowel disease.
Through rapid advances, genome-wide association studies (GWAS) have identified almost 100 susceptibility genes which confer an… 
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