Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors.

@article{Deretic2012AutophagyAA,
  title={Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors.},
  author={Vojo Deretic},
  journal={Current opinion in immunology},
  year={2012},
  volume={24 1},
  pages={21-31}
}
Autophagy is rapidly developing into a new immunological paradigm. The latest links now include overlaps between autophagy and innate immune signaling via TBK-1 and IKKα/β, and the role of autophagy in inflammation directed by the inflammasome. Autophagy's innate immunity connections include responses to pathogen and damage-associated molecular patterns including alarmins such as HMGB1 and IL-1β, Toll-like receptors, Nod-like receptors including NLRC4, NLRP3 and NLRP4, and RIG-I-like receptors… CONTINUE READING