• Publications
  • Influence
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
  • M. Abreu
  • Medicine, Biology
  • Nature Reviews Immunology
  • 1 February 2010
A single layer of epithelial cells lines the small and large intestines and functions as a barrier between commensal bacteria and the rest of the body. Ligation of Toll-like receptors (TLRs) onExpand
  • 938
  • 71
Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial
The lumenal surface of the colonic epithelium is continually exposed to Gram-negative commensal bacteria and LPS. Recognition of LPS by Toll-like receptor (TLR)-4 results in proinflammatory geneExpand
  • 676
  • 35
Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis.
Inflammatory bowel disease (IBD) arises from a dysregulated mucosal immune response to luminal bacteria. Toll-like receptor (TLR)4 recognizes LPS and transduces a proinflammatory signal through theExpand
  • 457
  • 22
  • PDF
TLR4 and MD-2 Expression Is Regulated by Immune-mediated Signals in Human Intestinal Epithelial Cells*
The normal intestinal epithelium is not inflamed despite contact with a high density of commensal bacteria. Intestinal epithelial cells (IEC) express low levels of TLR4 and MD-2 and areExpand
  • 359
  • 22
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids
Inflammatory T helper 17 cells in humans are distinguished by selective expression of MDR1 and are enriched in the gut of patients with Crohn’s disease.
  • 260
  • 22
  • PDF
Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.
BACKGROUND & AIMS We recently showed that mice deficient in Toll-like receptor 4 (TLR4) or its adapter molecule MyD88 have increased signs of colitis compared with wild-type (WT) mice after dextranExpand
  • 401
  • 20
Antibiotic Therapy in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
The etiology of inflammatory bowel disease (IBD) is unknown but may relate to an unidentified bacterial pathogen or an immunological reaction to gut microbiota. Antibiotics have therefore beenExpand
  • 407
  • 20
6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.
BACKGROUND & AIMS Approximately 40% of inflammatory bowel disease (IBD) patients fail to benefit from 6-mercaptopurine (6-MP)/azathioprine (AZA). Recent reports suggest 6-thioguanine nucleotideExpand
  • 456
  • 19
Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.
BACKGROUND & AIMS Chronic inflammation is a risk factor for colon cancer in patients with ulcerative colitis (UC). The molecular mechanisms linking inflammation and colon carcinogenesis areExpand
  • 490
  • 18
Placental transfer of anti-tumor necrosis factor agents in pregnant patients with inflammatory bowel disease.
BACKGROUND & AIMS Some women with inflammatory bowel disease require therapy with tumor necrosis factor (TNF) antagonists during pregnancy. It is not clear whether these drugs are transferred to theExpand
  • 339
  • 18
  • PDF