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IRGM wt Allele

Known as: LRG47, Immunity-Related GTPase Family, M wt Allele, MGC149263 
Human IRGM wild-type allele is located in the vicinity of 5q33.1 and is approximately 2 kb in length. This allele, which encodes immunity-related… Expand
National Institutes of Health

Related topics

Related topics

6 relations
5q33.1AutophagyHydrolysisImmunity
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Broader (1)

IRGM gene

Papers overview

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Highly Cited
2013
Highly Cited
2013
IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins
Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance… Expand
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2011
2011
Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a… Expand
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2010
2010
Regulation of macrophage motility by Irgm1.
IRG are a family of IFN-regulated proteins that are critical for resistance to infection. Mouse IRG proteins are divided into GMS… Expand
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2010
2010
The Mouse Resistance Protein Irgm1 (LRG-47): A Regulator or an Effector of Pathogen Defense?
The interferon-γ (IFNγ)–inducible IRG proteins are a distinctive cytoplasmic GTPase family encoded by about 20 genes in the C57BL… Expand
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2009
2009
Balance of Irgm protein activities determines IFN-gamma-induced host defense.
The immunity-related GTPases (IRG), also known as p47 GTPases, are a family of proteins that are tightly regulated by IFNs at the… Expand
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Highly Cited
2008
Highly Cited
2008
Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains… Expand
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Highly Cited
2008
Highly Cited
2008
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death
Mice deficient in the interferon-γ (IFN-γ)-inducible, immunity-related GTPase Irgm1 have defective host resistance to a variety… Expand
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Highly Cited
2005
Highly Cited
2005
p47 GTPases regulate Toxoplasma gondii survival in activated macrophages.
The cytokine gamma interferon (IFN-gamma) is critical for resistance to Toxoplasma gondii. IFN-gamma strongly activates… Expand
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Highly Cited
2005
Highly Cited
2005
Mice Deficient in LRG-47 Display Enhanced Susceptibility to Trypanosoma cruzi Infection Associated with Defective Hemopoiesis and Intracellular Control of Parasite Growth
IFN-γ is known to be required for host control of intracellular Trypanosoma cruzi infection in mice, although the basis of its… Expand
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1995
1995
Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family.
The response of macrophages to agents such as lipopolysaccharide (LPS) and interferon (IFN) includes the transcriptional… Expand
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