Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

IRGM wt Allele

Known as: LRG47, Immunity-Related GTPase Family, M wt Allele, MGC149263 
Human IRGM wild-type allele is located in the vicinity of 5q33.1 and is approximately 2 kb in length. This allele, which encodes immunity-related… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2011
Highly Cited
2011
An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a… Expand
  • figure 1
  • table 1
Highly Cited
2011
Highly Cited
2011
The IFN-inducible immunity-related p47 GTPase Irgm1 has been linked to Crohn disease as well as susceptibility to tuberculosis… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
2010
2010
IRG are a family of IFN‐regulated proteins that are critical for resistance to infection. Mouse IRG proteins are divided into GMS… Expand
Highly Cited
2009
Highly Cited
2009
The immunity‐related GTPases (IRG), also known as p47 GTPases, are a family of proteins that are tightly regulated by IFNs at the… Expand
Highly Cited
2008
Highly Cited
2008
Mice deficient in the interferon-γ (IFN-γ)-inducible, immunity-related GTPase Irgm1 have defective host resistance to a variety… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 8
Highly Cited
2008
Highly Cited
2008
The role of Toll‐like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains… Expand
Highly Cited
2005
Highly Cited
2005
IFN-γ is known to be required for host control of intracellular Trypanosoma cruzi infection in mice, although the basis of its… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2005
Highly Cited
2005
ABSTRACT The cytokine gamma interferon (IFN-γ) is critical for resistance to Toxoplasma gondii. IFN-γ strongly activates… Expand
Highly Cited
1995
Highly Cited
1995
Abstract The response of macrophages to agents such as lipopolysaccharide (LPS) and interferon (IFN) includes the transcriptional… Expand