Skip to search formSkip to main contentSkip to account menu

IRGM wt Allele

Known as: LRG47, Immunity-Related GTPase Family, M wt Allele, MGC149263 
Human IRGM wild-type allele is located in the vicinity of 5q33.1 and is approximately 2 kb in length. This allele, which encodes immunity-related… 
National Institutes of Health

Related topics

Related topics

6 relations
5q33.1AutophagyHydrolysisImmunity

Broader (1)

IRGM gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins
Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance… 
Highly Cited
2011
Highly Cited
2011
Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a… 
Highly Cited
2011
Highly Cited
2011
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
The IFN-inducible immunity-related p47 GTPase Irgm1 has been linked to Crohn disease as well as susceptibility to tuberculosis… 
2011
2011
Concanavalin A/IFN-Gamma Triggers Autophagy-Related Necrotic Hepatocyte Death through IRGM1-Mediated Lysosomal Membrane Disruption
Interferon-gamma (IFN-γ), a potent Th1 cytokine with multiple biological functions, can induce autophagy to enhance the clearance… 
Highly Cited
2009
Highly Cited
2009
Balance of Irgm protein activities determines IFN‐γ‐induced host defense
The immunity‐related GTPases (IRG), also known as p47 GTPases, are a family of proteins that are tightly regulated by IFNs at the… 
Highly Cited
2008
Highly Cited
2008
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death
Mice deficient in the interferon-γ (IFN-γ)-inducible, immunity-related GTPase Irgm1 have defective host resistance to a variety… 
Highly Cited
2008
Highly Cited
2008
Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, ‐4 and ‐9
The role of Toll‐like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains… 
Highly Cited
2005
Highly Cited
2005
p47 GTPases Regulate Toxoplasma gondii Survival in Activated Macrophages
ABSTRACT The cytokine gamma interferon (IFN-γ) is critical for resistance to Toxoplasma gondii. IFN-γ strongly activates… 
Highly Cited
2005
Highly Cited
2005
Mice Deficient in LRG-47 Display Enhanced Susceptibility to Trypanosoma cruzi Infection Associated with Defective Hemopoiesis and Intracellular Control of Parasite Growth
IFN-γ is known to be required for host control of intracellular Trypanosoma cruzi infection in mice, although the basis of its… 
Highly Cited
1995
Highly Cited
1995
Identification of an endotoxin and IFN‐inducible cDNA: possible identification of a novel protein family
Abstract The response of macrophages to agents such as lipopolysaccharide (LPS) and interferon (IFN) includes the transcriptional… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)