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IRGM wt Allele
Known as:
LRG47
, Immunity-Related GTPase Family, M wt Allele
, MGC149263
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Human IRGM wild-type allele is located in the vicinity of 5q33.1 and is approximately 2 kb in length. This allele, which encodes immunity-related…
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National Institutes of Health
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Related topics
Related topics
6 relations
5q33.1
Autophagy
Hydrolysis
Immunity
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Broader (1)
IRGM gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins
A. Haldar
,
H. A. Saka
,
+6 authors
J. Coers
PLoS Pathogens
2013
Corpus ID: 867321
Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance…
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Highly Cited
2011
Highly Cited
2011
Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
K. King
,
Justin D Lew
,
+4 authors
M. Goodell
PLoS ONE
2011
Corpus ID: 294063
An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a…
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Highly Cited
2011
Highly Cited
2011
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
K. King
,
M. Baldridge
,
+11 authors
M. Goodell
Blood
2011
Corpus ID: 22122145
The IFN-inducible immunity-related p47 GTPase Irgm1 has been linked to Crohn disease as well as susceptibility to tuberculosis…
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2011
2011
Concanavalin A/IFN-Gamma Triggers Autophagy-Related Necrotic Hepatocyte Death through IRGM1-Mediated Lysosomal Membrane Disruption
Chih-Peng Chang
,
Ming-Chen Yang
,
H. Lei
PLoS ONE
2011
Corpus ID: 1853285
Interferon-gamma (IFN-γ), a potent Th1 cytokine with multiple biological functions, can induce autophagy to enhance the clearance…
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Highly Cited
2009
Highly Cited
2009
Balance of Irgm protein activities determines IFN‐γ‐induced host defense
S. Henry
,
X. Daniell
,
+9 authors
G. Taylor
Journal of Leukocyte Biology
2009
Corpus ID: 10236211
The immunity‐related GTPases (IRG), also known as p47 GTPases, are a family of proteins that are tightly regulated by IFNs at the…
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Highly Cited
2008
Highly Cited
2008
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death
C. Feng
,
Lixin Zheng
,
+9 authors
A. Sher
Nature Immunology
2008
Corpus ID: 205361807
Mice deficient in the interferon-γ (IFN-γ)-inducible, immunity-related GTPase Irgm1 have defective host resistance to a variety…
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Highly Cited
2008
Highly Cited
2008
Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, ‐4 and ‐9
C. Hölscher
,
N. Reiling
,
+12 authors
S. Ehlers
European Journal of Immunology
2008
Corpus ID: 33272118
The role of Toll‐like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains…
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Highly Cited
2005
Highly Cited
2005
p47 GTPases Regulate Toxoplasma gondii Survival in Activated Macrophages
B. Butcher
,
Robert I Greene
,
+5 authors
G. Taylor
Infection and Immunity
2005
Corpus ID: 19234854
ABSTRACT The cytokine gamma interferon (IFN-γ) is critical for resistance to Toxoplasma gondii. IFN-γ strongly activates…
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Highly Cited
2005
Highly Cited
2005
Mice Deficient in LRG-47 Display Enhanced Susceptibility to Trypanosoma cruzi Infection Associated with Defective Hemopoiesis and Intracellular Control of Parasite Growth
H. Santiago
,
C. Feng
,
+8 authors
A. Sher
Journal of Immunology
2005
Corpus ID: 12876705
IFN-γ is known to be required for host control of intracellular Trypanosoma cruzi infection in mice, although the basis of its…
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Highly Cited
1995
Highly Cited
1995
Identification of an endotoxin and IFN‐inducible cDNA: possible identification of a novel protein family
J. Sorace
,
Robert J. Johnson
,
D. Howard
,
B. Drysdale
Journal of Leukocyte Biology
1995
Corpus ID: 36303177
Abstract The response of macrophages to agents such as lipopolysaccharide (LPS) and interferon (IFN) includes the transcriptional…
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