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INT 131

Known as: INT-131, INT131 
National Institutes of Health

Related topics

Related topics

4 relations
AMG 131T 131 cpd

Broader (2)

QuinolinesSulfonamides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Selective peroxisome proliferator‐activated receptor‐gamma modulator, INT131 exhibits anti‐inflammatory effects in an EcoHIV mouse model
Despite the use of antiretroviral therapy for the treatment of HIV‐1 infection, cognitive impairments, that is, HIV‐1‐associated… 
2017
2017
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor central to fatty acid and glucose homeostasis. PPAR… 
2017
2017
Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator
The mechanisms underlying the enhancement of insulin sensitivity by selective peroxisome proliferator-activated receptor… 
Highly Cited
2014
Highly Cited
2014
Can a Selective PPARγ Modulator Improve Glycemic Control in Patients With Type 2 Diabetes With Fewer Side Effects Compared With Pioglitazone?
OBJECTIVE INT131 besylate is a potent, nonthiazolidinedione, selective peroxisome proliferator–activated receptor γ (PPAR… 
2013
2013
Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.
Review
2013
Review
2013
Obesity and thyroid cancer: epidemiologic associations and underlying mechanisms
The incidence of thyroid cancer has been rising over the past few decades along with a parallel increase in obesity. 
2012
2012
Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice.
INT131 is a potent non-thiazolidinedione (TZD)-selective peroxisome proliferator-activated receptor-γ modulator being developed… 
2009
2009
INT131: a selective modulator of PPAR gamma.
The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR gamma; NR1C3) plays a central role in… 
Review
2009
Review
2009
INT-131, a PPARgamma agonist for the treatment of type 2 diabetes.
INT-131, a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, is in… 
Highly Cited
2008
Highly Cited
2008
The Development of INT131 as a Selective PPARγ Modulator: Approach to a Safer Insulin Sensitizer
INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated… 
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