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INT 131

Known as: INT-131, INT131 
 
National Institutes of Health

Related topics

Related topics

4 relations
AMG 131T 131 cpd

Broader (2)

QuinolinesSulfonamides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor central to fatty acid and glucose homeostasis. PPAR… Expand
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2017
2017
Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator
The mechanisms underlying the enhancement of insulin sensitivity by selective peroxisome proliferator-activated receptor… Expand
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2014
2014
Can a Selective PPARγ Modulator Improve Glycemic Control in Patients With Type 2 Diabetes With Fewer Side Effects Compared With Pioglitazone?
OBJECTIVE INT131 besylate is a potent, nonthiazolidinedione, selective peroxisome proliferator–activated receptor γ (PPAR… Expand
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Review
2013
Review
2013
Obesity and thyroid cancer: epidemiologic associations and underlying mechanisms
The incidence of thyroid cancer has been rising over the past few decades along with a parallel increase in obesity. 
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2013
2013
Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.
PPARγ is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This… Expand
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2012
2012
Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice.
INT131 is a potent non-thiazolidinedione (TZD)-selective peroxisome proliferator-activated receptor-γ modulator being developed… Expand
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Highly Cited
2009
Highly Cited
2009
INT131: a selective modulator of PPAR gamma.
The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR gamma; NR1C3) plays a central role in… Expand
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Review
2009
Review
2009
INT-131, a PPARgamma agonist for the treatment of type 2 diabetes.
INT-131, a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, is in… Expand
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2009
2009
PAR-1622 is a selective peroxisome proliferator-activated receptor γ partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention
Peroxisome proliferator-activated receptor (PPAR) γ is known to be a key regulator of insulin resistance. PAR-1622 is a novel… Expand
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Highly Cited
2008
Highly Cited
2008
The Development of INT131 as a Selective PPARγ Modulator: Approach to a Safer Insulin Sensitizer
INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated… Expand
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