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INT 131
Known as:
INT-131
, INT131
National Institutes of Health
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Related topics
Related topics
4 relations
AMG 131
T 131 cpd
Broader (2)
Quinolines
Sulfonamides
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Selective peroxisome proliferator‐activated receptor‐gamma modulator, INT131 exhibits anti‐inflammatory effects in an EcoHIV mouse model
Amila Omeragic
,
Michael F. Saikali
,
S. Currier
,
D. Volsky
,
C. Cummins
,
R. Bendayan
FASEB journal : official publication of the…
2019
Corpus ID: 210043848
Despite the use of antiretroviral therapy for the treatment of HIV‐1 infection, cognitive impairments, that is, HIV‐1‐associated…
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2017
2017
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.
R. Frkic
,
Yuanjun He
,
+7 authors
J. Bruning
Journal of medicinal chemistry
2017
Corpus ID: 20621488
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor central to fatty acid and glucose homeostasis. PPAR…
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2017
2017
Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator
Xinni Xie
,
Wei Chen
,
+5 authors
Lili Wang
Front. Pharmacol.
2017
Corpus ID: 28906493
The mechanisms underlying the enhancement of insulin sensitivity by selective peroxisome proliferator-activated receptor…
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Highly Cited
2014
Highly Cited
2014
Can a Selective PPARγ Modulator Improve Glycemic Control in Patients With Type 2 Diabetes With Fewer Side Effects Compared With Pioglitazone?
A. DePaoli
,
L. Higgins
,
R. Henry
,
C. Mantzoros
,
F. Dunn
Diabetes Care
2014
Corpus ID: 14760040
OBJECTIVE INT131 besylate is a potent, nonthiazolidinedione, selective peroxisome proliferator–activated receptor γ (PPAR…
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2013
2013
Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.
Joshua P. Taygerly
,
L. McGee
,
+29 authors
Motonao Nakamura
Bioorganic & medicinal chemistry
2013
Corpus ID: 22884410
Review
2013
Review
2013
Obesity and thyroid cancer: epidemiologic associations and underlying mechanisms
K. Pazaitou-Panayiotou
,
S. Polyzos
,
C. Mantzoros
Obesity reviews : an official journal of the…
2013
Corpus ID: 5524007
The incidence of thyroid cancer has been rising over the past few decades along with a parallel increase in obesity.
2012
2012
Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice.
D. Lee
,
Hu Huang
,
Kangduk Choi
,
C. Mantzoros
,
Young-Bum Kim
American journal of physiology. Endocrinology and…
2012
Corpus ID: 28227282
INT131 is a potent non-thiazolidinedione (TZD)-selective peroxisome proliferator-activated receptor-γ modulator being developed…
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2009
2009
INT131: a selective modulator of PPAR gamma.
A. Motani
,
Zhulun Wang
,
+14 authors
Yang Li
Journal of molecular biology
2009
Corpus ID: 26028497
The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR gamma; NR1C3) plays a central role in…
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Review
2009
Review
2009
INT-131, a PPARgamma agonist for the treatment of type 2 diabetes.
U. Kintscher
,
M. Goebel
Current opinion in investigational drugs
2009
Corpus ID: 9360485
INT-131, a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, is in…
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Highly Cited
2008
Highly Cited
2008
The Development of INT131 as a Selective PPARγ Modulator: Approach to a Safer Insulin Sensitizer
L. Higgins
,
C. Mantzoros
PPAR research
2008
Corpus ID: 18787045
INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated…
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