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Emerging roles of Wnts in the adult nervous system
TLDR
The latest insights into the function of Wnt signalling in the adult nervous system and therapeutic opportunities for neurodegenerative diseases such as Alzheimer's and Parkinson's disease are discussed.
Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme
TLDR
It is reported here that bovine brain AChE, as well as the human and mouse recombinant enzyme, accelerates amyloid formation from wild-type A beta and a mutant A beta peptide, which alone produces few amyloids-like fibrils.
Settlement of benthic marine invertebrates
TLDR
This review analyses the settlement process, attempting to integrate aspects related to different levels of organization (i.e. ecological-physiological-molecular) and using the use of artificial inducers in studying settlement induction, until more effective natural inducers are isolated and characterized.
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
TLDR
It is reported that microregional catalytic H( 2)O(2) production, combined with the exhaustion of reducing agents, may mediate the neurotoxicity of Abeta in Alzheimer's disease, and inhibitors of this novel activity may be of therapeutic value.
Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease
TLDR
Lithium and rosiglitazone, possibly by the activation of the Wnt signaling pathway, reduce various AD neuropathological markers and may be considered as potential therapeutic agents against the disease.
Wnt-7a Modulates the Synaptic Vesicle Cycle and Synaptic Transmission in Hippocampal Neurons*
TLDR
Electrophysiological analysis on adult rat hippocampal slices indicates that Wnt-7a, but not WNT-5a, increases neurotransmitter release in CA3-CA1 synapses by decreasing paired pulse facilitation and increasing the miniature excitatory post-synaptic currents frequency, indicating that the presynaptic function of rat hippocampusal neurons is modulated by the canonical Wnt signaling.
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons*
TLDR
The studies indicate that the Wnt-5a/JNK pathway modulates the postsynaptic region of mammalian synapse directing the clustering and distribution of the physiologically relevant scaffold protein, PSD-95.
Wnt signaling in neuroprotection and stem cell differentiation
TLDR
Activation of Wnt signaling protects neurons against neurotoxic injuries, including both amyloid-beta (Abeta) fibrils and Abeta oligomers by using either lithium, an inhibitor of the glycogen-synthase-kinase-3 beta (GSK-3beta), or different Wnt ligands, and several molecules which activate well known neurotransmitter systems are able by crosstalk to activate Wnt/beta-catenin signaling.
Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.
TLDR
The Wnt-3a ligand was indeed able to overcome toxic effects induced by Abeta in hippocampal neurons, including a neuronal impairment on cell survival, and the hypothesis that a loss of function of Wnt signaling may play a role in the progression of neurodegenerative diseases such as Alzheimer's disease is supported.
The -Helical to -Strand Transition in the Amino-terminal Fragment of the Amyloid -Peptide Modulates Amyloid Formation *
TLDR
It is proposed that Aβ exists in an equilibrium between two species: one “able’ and another “unable” to form amyloid, depending on the secondary structure adopted by the N-terminal domain.
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