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Serum irisin levels in new-onset type 2 diabetes.
Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner.
TLDR
This study shows that ER stress-induced activation of activating transcription factor (ATF)-6 plays an important role in the development of beta-cell dysfunction.
Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3.
Beneficial Effects of Evogliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, on Adiposity with Increased Ppargc1a in White Adipose Tissue in Obese Mice
TLDR
It is demonstrated for the first time that pharmacological DPP4 inhibition by evogliptin directly causes fat loss in established obese mice, providing insight into the regulation of energy storage in WAT caused by DPP 4 inhibition.
Endoplasmic Reticulum Stress and Insulin Biosynthesis: A Review
TLDR
The relationship between ER stress and diabetes and how ER stress controls insulin biosynthesis is reviewed and it is suggested that reduction of ER stress could be a therapeutic target for diabetes.
PAR-1622 is a selective peroxisome proliferator-activated receptor γ partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention
TLDR
The results suggest that PAR-1622 is a selective partial activator of PPARγ and has excellent antihyperglycemic activities and a broad safety profile for fluid retention.
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