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Role of leptin in the neuroendocrine response to fasting
It is proposed that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin, and preventing the starvation-induced fall in leptin with exogenous leptin substantially blunts the changes in gonadal, adrenal and thyroid axes in male mice, and prevents the starve-induced delay in ovulation in female mice.
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise.
- J. Huh, G. Panagiotou, +4 authors C. Mantzoros
- Biology, MedicineMetabolism: clinical and experimental
- 1 December 2012
Tissue arrays demonstrated that in humans, the FNDC5 gene is predominantly expressed in muscle, and age and muscle mass are the primary predictors of circulating irisin, with young male athletes having several fold higher irisin levels than middle-aged obese women.
Adverse metabolic and cardiovascular consequences of circadian misalignment
- F. Scheer, M. Hilton, C. Mantzoros, S. Shea
- Biology, MedicineProceedings of the National Academy of Sciences
- 17 March 2009
The findings demonstrate the adverse cardiometabolic implications of circadian misalignment, as occurs acutely with jet lag and chronically with shift work, on metabolic, autonomic, and endocrine predictors of obesity, diabetes, and cardiovascular risk.
Mediterranean Diet and Incidence of and Mortality From Coronary Heart Disease and Stroke in Women
A greater adherence to the Mediterranean diet, as reflected by a higher Alternate Mediterranean Diet Score, was associated with a lower risk of incident CHD and stroke in women.
Dietary Patterns and Risk of Mortality From Cardiovascular Disease, Cancer, and All Causes in a Prospective Cohort of Women
- C. Heidemann, M. Schulze, O. Franco, R. V. van Dam, C. Mantzoros, F. Hu
- 15 July 2008
Greater adherence to the prudent pattern may reduce the risk of cardiovascular and total mortality, whereas greater adhere to the Western pattern may increase the risk among initially healthy women.
The role of adiponectin in cancer: a review of current evidence.
The pathophysiological mechanisms that underlie the association between adiponectin and malignancy in the context of a dysfunctional adipose tissue in obesity are examined and understanding of these mechanisms may be important for the development of preventive and therapeutic strategies against obesity-associated malignancies.
Adiponectin and cancer: a systematic review
Recent findings on the association of adiponectin with several malignancies as well as recent data on underlying molecular mechanisms that provide novel insights into the association between obesity and cancer risk are presented.
Circulating irisin in relation to insulin resistance and the metabolic syndrome.
- Kyung Hee Park, L. Zaichenko, +10 authors C. Mantzoros
- MedicineThe Journal of clinical endocrinology and…
- 20 September 2013
Irisin is associated with increased risk of MetS, cardiometabolic variables, and CVD in humans, indicating either increased secretion by adipose/muscle tissue and/or a compensatory increase of irisin to overcome an underlying irisin resistance in these subjects.
Diabetes mellitus and risk of breast cancer: A meta‐analysis
A meta‐analysis of case–control and cohort studies indicates that diabetes is associated with an increased risk of breast cancer.
Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence.
- D. Barb, Catherine J. Williams, A. Neuwirth, C. Mantzoros
- MedicineThe American journal of clinical nutrition
- 1 September 2007
Recent evidence supporting a role of serum adiponectin concentrations as a novel risk factor and possible diagnostic marker for obesity-related malignancies, including cancers of the breast, endometrium, colon, and prostate is reviewed.