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IL6ST gene

Known as: GP130 TRANSDUCER CHAIN, Interleukin 6 Signal Transducer (GP130, Oncostatin M Receptor) Gene, INTERLEUKIN 6 SIGNAL TRANSDUCER 
This gene plays a role in signal transduction and is putatively involved in embryonic development.
National Institutes of Health

Related topics

Related topics

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Cytokine SignalingIL6ST protein, humanSignal Transductiongp130 activity

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IL6ST wt Allele

Papers overview

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Highly Cited
2015
Highly Cited
2015
A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130
IL-6 is a major causative factor of inflammatory disease. Although IL-6 and its signaling pathways are promising targets, orally… 
Highly Cited
2010
Highly Cited
2010
Helicobacter pylori CagA Phosphorylation Status Determines the gp130-activated SHP2/ERK and JAK/STAT Signal Transduction Pathways in Gastric Epithelial Cells*
The Helicobacter pylori protein CagA may undergo tyrosine phosphorylation following its entry into human gastric epithelial cells… 
Highly Cited
2008
Highly Cited
2008
c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130
ABSTRACT Interleukin 6 (IL-6), a pleiotropic cytokine, functions in cells through its interaction with its receptor complex… 
Highly Cited
1998
Highly Cited
1998
Cloning and characterization of a novel class I cytokine receptor.
The human gp130 cDNA sequence was used as a query to search an expressed sequence tag database (dbEST) to identify cDNA sequences… 
Highly Cited
1998
Highly Cited
1998
Crystal structure of a cytokine‐binding region of gp130
The structure of the cytokine‐binding homology region of the cell surface receptor gp130 has been determined by X‐ray… 
Review
1997
Review
1997
Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development
Abstract The reactivation of an embryonic pattern of gene expression is a central feature common to virtually all forms of… 
Highly Cited
1995
Highly Cited
1995
Syp Associates with gp130 and Janus Kinase 2 in Response to Interleukin-11 in 3T3-L1 Mouse Preadipocytes (*)
Protein tyrosine phosphorylation and thus dephosphorylation are part of the interleukin (IL)-11 response in mouse 3T3-L1 cells… 
Highly Cited
1994
Highly Cited
1994
Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.
A cDNA encoding a human IL-12R subunit was isolated by expression cloning. This subunit is a 662 amino acid type I transmembrane… 
Highly Cited
1994
Highly Cited
1994
Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
Interleukin-6 (IL-6) exerts its action via a cell surface receptor complex consisting of two subunits, the IL-6 receptor and the… 
Highly Cited
1988
Highly Cited
1988
Characterization of a human cytomegalovirus glycoprotein complex (gcI).
Three distinct families of glycoprotein complexes present in the envelopes of human cytomegalovirus and designated gcI, gcII and… 
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