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IL6ST gene

Known as: GP130 TRANSDUCER CHAIN, Interleukin 6 Signal Transducer (GP130, Oncostatin M Receptor) Gene, INTERLEUKIN 6 SIGNAL TRANSDUCER 
This gene plays a role in signal transduction and is putatively involved in embryonic development.
National Institutes of Health

Related topics

Related topics

7 relations
Cytokine SignalingIL6ST protein, humanSignal Transductiongp130 activity

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IL6ST wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
T-cell receptor-mediated characteristic signaling pathway of peripheral blood T cells in dermatomyositis and polymyositis
Abstract The characteristics of T cell expression in peripheral blood have been previously described in dermatomyositis (DM) and… 
2011
2011
The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue.
OBJECTIVE Interleukin-6 (IL-6) is a proinflammatory cytokine with regulatory effects on the survival and differentiation of T… 
2011
2011
Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis.
Interleukin-6 (IL-6) is a key mediator of inflammation in rheumatoid arthritis (RA) and its actions may be controlled by the IL-6… 
Highly Cited
2001
Highly Cited
2001
Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases
ABSTRACT Interleukin-6 (IL-6) induces the activation of the Src family kinase Hck, which is associated with the IL-6 receptor… 
Review
1999
Review
1999
Signaling through Gp130: toward a general scenario of cytokine action.
Cytokines play roles in a wide range of responses such as immune response, hematopoiesis and inflammation. A large volume of… 
1997
1997
Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties.
1995
1995
Definition of a Composite Binding Site for gp130 in Human Interleukin-6 (*)
The helical cytokine interleukin-6 (IL-6) assembles a multiprotein receptor complex. The starting event in the activation of… 
1995
1995
Analysis of interleukin receptor gene expression in mouse fetal liver by quantitative polymerase chain reaction
We describe a simplified and sensitive polymerase chain reaction (PCR)‐based method for the quantification of low‐abundance RNA… 
1995
1995
Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11.
Human gp130 (IL6ST) is one of the most widely used chains of the cytokine receptor family. Indeed, it is involved in signal… 
Highly Cited
1994
Highly Cited
1994
Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
Interleukin-6 (IL-6) exerts its action via a cell surface receptor complex consisting of two subunits, the IL-6 receptor and the… 
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