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gp130 activity

Known as: gp130 
OBSOLETE (was not defined before being made obsolete). [GOC:jl]
National Institutes of Health

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2 relations
IL6ST geneIL6ST wt Allele

Papers overview

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2016
2016
Signal transduction of Interleukin-11 and Interleukin-6 α-Receptors
The cytokines Interleukin (IL)-11 and IL-6 are important mediators that regulate differentiation and proliferation of immune… 
2013
2013
Novel Small Molecules Disabling the IL-6/IL-6R/GP130 Heterohexamer Complex
Abstract : Interleukin-6 (IL-6) is a key signaling molecule in breast cancer cells. It is responsible for many cellular responses… 
2010
2010
Serum Soluble Glycoprotein 130 Concentration Is Inversely Related to Insulin Sensitivity in Women With Polycystic Ovary Syndrome
OBJECTIVE Insulin resistance might play a role in the pathogenesis of polycystic ovarian syndrome (PCOS). The family of… 
2009
2009
Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells
The gp130 system is a set of ligands and receptors that dominantly involves the activation of the JAK/STAT, Erk, and PI3K/Akt… 
2007
2007
Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFα
Negative regulation of cytokine signaling is critical for the generation of the appropriate cellular outcome in response to… 
1998
1998
A New Type of Cytokine Receptor Antagonist Directly Targeting gp130*
The interleukin-6-type family of cytokines bind to receptor complexes that share gp130 as a common signal-transducing subunit. So… 
1998
1998
A selective switch-on system for self-renewal of embryonic stem cells using chimeric cytokine receptors.
Propagation of embryonic stem (ES) cells with an undifferentiated pluripotential phenotype depends on leukemia inhibitory factor… 
1996
1996
IL-6 antisense-mediated growth inhibition of a choriocarcinoma cell line: an intracellular autocrine growth mechanism.
The growth of tumor cells can be regulated by a variety of cytokines. To investigate the pathogenesis of choriocarcinoma and… 
1995
1995
Biosynthetic and glycosylation events of the IL-6 receptor beta-subunit, gp130.
It is now recognized that the beta-subunit of the interleukin-6 (IL-6) receptor, also known as gp130, is a common signal… 
Highly Cited
1994
Highly Cited
1994
Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin M receptors.
Oncostatin M (OM) and interleukin 6 (IL-6) are functionally related cytokines, which trigger similar biological responses because… 
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