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Soluble epoxide hydrolase is a therapeutic target for acute inflammation.
It is demonstrated that the soluble epoxide hydrolase (sEH) is a key pharmacologic target for treating acute systemic inflammation and has therapeutic efficacy in the treatment and management of acute inflammatory diseases. Expand
Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors
It is demonstrated that the combination therapy of NSAIDs and sEHIs produces significantly beneficial effects that are additive for alleviating pain and enhanced effects in reducing COX-2 protein expression and shifting oxylipin metabolomic profiles. Expand
Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges
A comprehensive list of inhibitors of nitric oxide synthases based on their structural characteristics, with an emphasis on major advances in this field, is discussed in this paper. Expand
Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
Investigation of whether heparin mobilizes MPO from vascular compartments in humans and whether this translates into increased vascular NO bioavailability and function adds to the growing body of evidence for a causal role of MPO in compromised vascular NO signaling in humans. Expand
Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions
In this review, current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels is summarized. Expand
Neural differentiation of pluripotent mouse embryonal carcinoma cells by retinoic acid: inhibitory effect of serum.
In both embryonal carcinoma (EC) and embryonic stem (ES) cells, the differentiation pathway entered after treatment with retinoic acid (RA) varies as it is based upon different conditions of culture.Expand
The comparison of impedance-based method of cell proliferation monitoring with commonly used metabolic-based techniques.
The study shows the impedance-based detection of viable adherent cells is a valuable approach for cytokinetics and pharmacological studies, however, the specific morphological characteristics of cell lines have to be considered employing this method for determination of cell proliferation without using other reference methods. Expand
Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase
ADMA profoundly impairs nitric oxide synthesis of PMNs, resulting in increased PMN adhesion to endothelial cells, superoxide generation, and release of MPO, and MPO is identified as a regulatory switch for ADMA bioavailability under inflammatory conditions. Expand
Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease.
Plasma MPO levels were not elevated in patients with stable CAD, suggesting that systemic release of MPO is not a characteristic feature of asymptomatic CAD. Expand
Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin.
It is shown for the first time that microcystin-LR could interfere with macrophage receptors that are responsible for triggering the above-mentioned signaling pathways and provide an interesting mechanistic explanation of some adverse health outcomes associated with toxic cyanobacteria and MCs. Expand