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Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs.
The Perlman syndrome-associated protein DIS3L2 is identified as an oligo(U)-binding and processing exoribonuclease that specifically targets uridylated pre-let-7 in vivo and is established as the missing component of the LIN28-TUT4/7-DIS3L 2 pathway required for the repression of let- 7 in pluripotent cells. Expand
Neural differentiation of pluripotent mouse embryonal carcinoma cells by retinoic acid: inhibitory effect of serum.
In both embryonal carcinoma (EC) and embryonic stem (ES) cells, the differentiation pathway entered after treatment with retinoic acid (RA) varies as it is based upon different conditions of culture.Expand
Alkaline Phosphatase in Stem Cells
The role of alkaline phosphatase as a stem cell marker is discussed in detail and the known facts of its role in and potential significance for the identification of stem cells are focused on. Expand
FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells.
expression of a dominant-negative Ras mutant resulted in a partial reversal of growth inhibition while expression of constitutively activated Ras led to Erk-dependent growth arrest, further demonstrating the role of the Ras/Erk pathway in this phenotype. Expand
Targeted disruption of fibroblast growth factor receptor-1 blocks maturation of visceral endoderm and cavitation in mouse embryoid bodies.
The results indicate that FGFR-1 may play a vital role in endoderm formation and that the addition of exogenous FGF-2 further reduced the expression of AFPmRNA in differentiating mutant EBs, corresponding morphological changes were not observed. Expand
The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo.
The findings suggest the existence of a dual role for p27, one being a classical regulation of cell cycle via inhibition of cyclin-dependent kinases (CDK), and the other being participation in the establishment and/or maintenance of differentiated status that is realized in conjunction with D-type cyclins. Expand
Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases
It is concluded that inhibition of histone deacetylases caused dynamic reorganization of chromatin in parallel with changes in its epigenetic modifications. Expand
Levels and Interactions of p27, Cyclin D3, and CDK4 During the Formation and Maintenance of the Corpus Luteum in Mice1
While inhibition of proliferation is underlaid by the progressive loss of positive regulators of the cell cycle, including cyclins and CDK2, maintenance of the luteal phenotype is driven by up-regulated levels of p27 and cyclin D3, at least partially owing to formation of p 27/cyclin D 3/CDK4 trimers. Expand
ABC transporters affect the detection of intracellular oxidants by fluorescent probes
The determination of intracellular ROS and mitochondrial potential by the selected probes is significantly altered by ABC transporter activities. Expand
The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.
The short term stabilization of HIF mediated by the PHD inhibitors JNJ and DMOG and hypoxia did not prevent the spontaneous loss of pluripotency markers in mESC, however, it significantly downregulated the proliferation of these cells. Expand