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IL6ST wt Allele

Known as: CDw130, Interleukin 6 Signal Transducer (GP130, Oncostatin M Receptor) wt Allele, GP130 
Human IL6ST wild-type allele is located in the vicinity of 5q11 and is approximately 60 kb in length. This allele, which encodes interleukin-6… 
National Institutes of Health

Related topics

Related topics

8 relations
5q11Cytokine SignalingHomo sapiensSignal Transduction

Broader (1)

IL6ST gene

Narrower (1)

interleukin-11 receptor activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
AB0080 In Both SLE and Seropositive RA, the Interleukin-6 (IL-6) System is Active, and Shifted towards Trans-Signalling
Background IL-6 signals via a receptor consisting of gp130 (CD130) and either membrane-bound IL-6 receptor α (CD126) present on… 
2013
2013
A10.10 Examination of IL-6, TNF I and II Receptor Distribution on Peripheral Blood Mononuclear Cells (PBMC) in Seropositive and Seronegative Rheumatoid Arthritis (RA)
Background and Objectives Despite significant clinical overlap, genetic evidence and, in part, response to therapy distinguish… 
2011
2011
The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue.
OBJECTIVE Interleukin-6 (IL-6) is a proinflammatory cytokine with regulatory effects on the survival and differentiation of T… 
2011
2011
T cells in Rheumatoid Arthritis
Identification of the role of T cells and their interaction with other cell types remains a major challenge to our understanding… 
Highly Cited
2006
Highly Cited
2006
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.
OBJECTIVE Soluble gp130 is the naturally occurring antagonist of the interleukin-6 (IL-6)/soluble IL-6 receptor (sIL-6R) complex… 
Highly Cited
2005
Highly Cited
2005
Clonal plasma cells from monoclonal gammopathy of undetermined significance, multiple myeloma and plasma cell leukemia show different expression profiles of molecules involved in the interaction with…
The immunological bone marrow (BM) microenvironment plays a major role in controlling growth and survival of clonal plasma cells… 
Highly Cited
2000
Highly Cited
2000
Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis.
In an attempt to isolate disease-associated autoantigens in rheumatoid arthritis (RA), we cloned a new autoantigen named gp130… 
1999
1999
CD130 rather than CD126 expression is associated with disease activity in multiple myeloma
We analysed the expression of both components of IL‐6R, CD126 the ligand binding protein and CD130 the signal transducing protein… 
Review
1997
Review
1997
CD antigens 1996.
THE RESULTS OF THE 6th International Workshop on Human Leukocyte Differentiation Antigens were presented on November 10 through… 
1995
1995
Characterization of human thymic epithelial cell surface antigens: Phenotypic similarity of thymic epithelial cells to epidermal keratinocytes
Cellular interactions between developing thymocytes and cells of the thymic microenvironment are necessary for maturation of… 
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