IFNGR2 gene

Known as: INTERFERON-GAMMA RECEPTOR, ACCESSORY FACTOR FOR, AF-1, IFGR2 
This gene is involved in receptor-mediated signal transduction in the interferon gamma signaling pathway and mediates innate immune responses.
National Institutes of Health

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Antiviral ResponseCytokine Signaling ProcessIFNGR2 protein, humanIntercellular Communication Process
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IFNGR2 wt Allele

Papers overview

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2013
2013
Haploinsufficiency at the human IFNGR2 locus contributes to mycobacterial disease.
Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare syndrome, the known genetic etiologies of which impair the… (More)
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Highly Cited
2012
Highly Cited
2012
Somatic STAT3 mutations in large granular lymphocytic leukemia.
BACKGROUND T-cell large granular lymphocytic leukemia is a rare lymphoproliferative disorder characterized by the expansion of… (More)
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Highly Cited
2009
Highly Cited
2009
Analyses of associations with asthma in four asthma population samples from Canada and Australia
Asthma, atopy, and related phenotypes are heterogeneous complex traits, with both genetic and environmental risk factors… (More)
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Review
2008
Review
2008
The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases.
Primary immunodeficiencies (PIDs) were long thought to be exclusively recessive traits -- autosomal recessive (AR) in most cases… (More)
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Review
2008
Review
2008
Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense.
Interferon (IFN) was originally identified as a substance 'interfering' with viral replication in vitro. The first IFNs to be… (More)
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Review
2007
Review
2007
Type I interferon receptors: biochemistry and biological functions.
The type I interferon (IFN)2 receptor (IFNAR) is comprised, as other cytokine receptors, of multiple components, in this case… (More)
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Highly Cited
2007
Highly Cited
2007
Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer.
Helicobacter pylori infection, the dominant risk factor for gastric cancers, has been shown to elicit T helper type 1 (Th1… (More)
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Highly Cited
2006
Highly Cited
2006
Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.
RATIONALE Interferon-gamma (IFN-gamma) is of central interest in the study of tuberculosis. A number of single-gene mutations… (More)
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2002
2002
Inherited disorders of IL-12- and IFNgamma-mediated immunity: a molecular genetics update.
In the last 6 years, considerable advances have been made in the molecular analysis of a rare clinical syndrome: Mendelian… (More)
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1998
1998
Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice.
To study the role of the interferon- (IFN) gammaR2 chain in IFN-gamma signaling and immune function, IFN-gammaR2-deficient mice… (More)
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