• Publications
  • Influence
Estrogen receptor null mice: what have we learned and where will they lead us?
TLDR
The recent successful generation of double knockout, or alpha beta ERKO mice of both sexes, suggests that this receptor is also not essential to survival and was most likely not a compensatory factor in the survival of the alpha ERKO.
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
TLDR
Prenatal male and female reproductive tract development can occur in the absence of estradiol receptor-mediated responsiveness, and the uteri and vagina do not respond in the animals with the estrogen receptor gene disruption.
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.
TLDR
Disruption of the estrogen receptor in humans need not be lethal and is important for bone maturation and mineralization in men as well as women.
Generation and reproductive phenotypes of mice lacking estrogen receptor beta.
TLDR
The generation of mice lacking estrogen receptor beta (ERbeta -/-) is described by insertion of a neomycin resistance gene into exon 3 of the coding gene by using homologous recombination in embryonic stem cells to determine the role of ERbeta in bone and cardiovascular homeostasis.
The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling*
TLDR
This minireview will discuss the recent progress toward the understanding of the molecular mechanisms of estrogen signaling, focusing on the following four pathways: 1) classical ligand-dependent; 2) ligand -independent; 3) DNA binding-independent; and 4) cell-surface (nongenomic) signaling.
Estrogen receptors and human disease.
  • B. Deroo, K. Korach
  • Biology, Medicine
    The Journal of clinical investigation
  • 1 March 2006
TLDR
This Review will describe diseases in which estrogen plays a role in the development or severity of disease, through the ER, which serves as the basis for many therapeutic interventions.
Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.
TLDR
It is suggested that estrogen action is required for fertility in male mice and that the mutation of the ER in ERKO males leads to reduced mating frequency, low sperm numbers, and defective sperm function.
Opposing LSD1 complexes function in developmental gene activation and repression programmes
TLDR
It is reported that the histone lysine demethylase, LSD1—a component of the CoREST-CtBP co-repressor complex—is required for late cell-lineage determination and differentiation during pituitary organogenesis, suggesting that temporal patterns of expression of specific components of LSD1 complexes modulate gene regulatory programmes in many mammalian organs.
Effect of testosterone and estradiol in a man with aromatase deficiency.
TLDR
The responses to androgen and estrogen in a man with a novel, homozygous inactivating mutation of cytochrome P-450 aromatase suggest a crucial role of estrogen in skeletal maturation.
Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β
TLDR
Loss of both receptors leads to an ovarian phenotype that is distinct from that of the individual ERKO mutants, which indicates that both receptors are required for the maintenance of germ and somatic cells in the postnatal ovary.
...
...