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The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
TLDR
It is concluded that the unique cellular arrangement of human islets has functional implications for islet cell function.
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International trial of the Edmonton protocol for islet transplantation.
TLDR
Islet transplantation with the use of the Edmonton protocol can successfully restore long-term endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus and unstable control, but insulin independence is usually not sustainable.
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The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
TLDR
It is shown that during fetal development and childhood, mRNAs for insulin and other islet cell autoantigens are expressed at low levels in the human thymus, and this finding provides a plausible explanation for the dominant protective effect of class III VNTRs, and suggests that diabetes susceptibility and resistance associated with IDDM2 may derive from the VN TR influence on INS transcription in the thymos.
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Age‐Related Osteogenic Potential of Mesenchymal Stromal Stem Cells from Human Vertebral Bone Marrow
TLDR
It is demonstrated that the number of MSCs with osteogenic potential (CFU‐F/ALP+) decreases early during aging in humans and may be responsible for the age‐related reduction in osteoblast number.
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Islet isolation assessment in man and large animals
TLDR
These general guidelines will be of assistance to standardize the assessment of islet isolations, making it possible to better interpret and compare procedures from different centers.
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Innervation patterns of autonomic axons in the human endocrine pancreas.
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Noninvasive in vivo imaging of pancreatic islet cell biology
TLDR
The results thus establish the basis for noninvasive in vivo investigations of complex cellular processes, like beta cell stimulus-response coupling, which can be performed longitudinally under both physiological and pathological conditions.
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ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors
TLDR
Adenosine triphosphate acts as an autocrine factor that integrates stimuli from the microenvironment and cellular energetics to tune the developmental and immunosuppressive program of the T cell in adaptive immune responses.
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Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
TLDR
Using oligonucleotide microarrays and real-time PCR of pancreatic islets isolated from humans with type 2 diabetes versus normal glucose-tolerant controls and beta cell-specific ARNT knockout mice, data suggest an important role for decreased ARNT and altered gene expression in the impaired islet function of human type 1 diabetes.
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Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis
TLDR
Modulation of sphingolipid-related proteins plays a role in the pathogenesis of recurrent FSGS and, moreover, that these proteins and enzymes might be targets of rituximab treatment.
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