FAQ

IDE gene

Known as: INSULIN-DEGRADING ENZYME, IDE, INSULYSIN 
This gene is involved in the catabolism of insulin and other bioactive peptides.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1955-2018
05010015019552017

Related topics

Related topics

5 relations
HydrolysisInsulinasePeptide MetabolismProteolysis
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
IDE gene
Hydrolysis
Proteolysis
Peptide Metabolism
Insulinase
Proteolytic Processing

Papers overview

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Highly Cited
2015
Highly Cited
2015
Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves.
BACKGROUND A finding of reduced aortic-valve leaflet motion was noted on computed tomography (CT) in a patient who had a stroke… (More)
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Highly Cited
2013
Highly Cited
2013
Effective Inter-Component Communication Mapping in Android with Epicc: An Essential Step Towards Holistic Security Analysis
Many threats present in smartphones are the result of interactions between application components, not just artifacts of single… (More)
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Highly Cited
2008
Highly Cited
2008
Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population
OBJECTIVE Genome-wide association studies have identified common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, HHEX/IDE, EXT2… (More)
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Highly Cited
2007
Highly Cited
2007
A genome-wide association study identifies novel risk loci for type 2 diabetes.
Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of genetic variants, most of… (More)
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Highly Cited
2007
Highly Cited
2007
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype… (More)
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Highly Cited
2006
Highly Cited
2006
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.
The thiazolidinediones, such as rosiglitazone, increase peripheral insulin sensitivity and their use is proposed for the… (More)
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Highly Cited
2003
Highly Cited
2003
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
Two substrates of insulin-degrading enzyme (IDE), amyloid beta-protein (Abeta) and insulin, are critically important in the… (More)
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Highly Cited
2003
Highly Cited
2003
Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele.
Abeta is the major component of amyloid plaques characterizing Alzheimer's disease (AD). Abeta accumulation can be affected by… (More)
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Highly Cited
2000
Highly Cited
2000
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
Progressive cerebral accumulation of amyloid beta-protein (Abeta) is an early and invariant feature of Alzheimer's disease… (More)
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Highly Cited
1994
Highly Cited
1994
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme.
Cerebral deposition of beta-amyloid peptide (beta A) is a hallmark of Alzheimer's disease. Concentration of beta A could play a… (More)
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