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IDE gene

Known as: INSULIN-DEGRADING ENZYME, IDE, INSULYSIN 
This gene is involved in the catabolism of insulin and other bioactive peptides.
National Institutes of Health

Related topics

Related topics

5 relations
HydrolysisInsulinasePeptide MetabolismProteolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Tale of stable interacting dark energy, observational signatures, and the H0 tension
We investigate the observational consequences of a novel class of stable interacting dark energy (IDE) models, featuring… 
Review
2014
Review
2014
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
Patients with established type 2 diabetes display both β-cell dysfunction and insulin resistance. To define fundamental processes… 
Highly Cited
2007
Highly Cited
2007
Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease*
Compelling evidence indicates that excess consumption of sugar-sweetened beverages plays an important role in the epidemic of… 
Review
2006
Review
2006
β-Amyloid Degradation and Alzheimer's Disease
Extensive β-amyloid (Aβ) deposits in brain parenchyma in the form of senile plaques and in blood vessels in the form of amyloid… 
Highly Cited
2004
Highly Cited
2004
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
Highly Cited
2003
Highly Cited
2003
Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death
Review
2003
Review
2003
Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease.
Review
2002
Review
2002
Biogenesis and metabolism of Alzheimer’s disease Aβ amyloid peptides
Highly Cited
1999
Highly Cited
1999
Identification and Characterization of Falcilysin, a Metallopeptidase Involved in Hemoglobin Catabolism within the Malaria Parasite Plasmodium falciparum*
The malaria parasite Plasmodium falciparum degrades hemoglobin in its acidic food vacuole for use as a major nutrient source. A… 
Highly Cited
1984
Highly Cited
1984
Multigrid solution of the Eu-ler equations for aircraft configurations
A multigrid scheme for solving the Euler equations is presented. The method has been successfully applied to two-dimensional… 
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