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Insulinase

Known as: Protease, Insulin, Insulin Degrading Enzyme, Insulysin 
An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Targeting the amyloid‐β (Aβ) peptide cascade has been at the heart of therapeutic developments in Alzheimer's disease (AD… Expand
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Highly Cited
2005
Highly Cited
2005
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there are few therapeutics that affect the… Expand
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Highly Cited
2004
Highly Cited
2004
Recent epidemiological evidence indicates that insulin resistance, a proximal cause of Type II diabetes [a non‐insulin dependent… Expand
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Highly Cited
2003
Highly Cited
2003
Two substrates of insulin-degrading enzyme (IDE), amyloid β-protein (Aβ) and insulin, are critically important in the… Expand
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Highly Cited
2003
Highly Cited
2003
Two substrates of insulin-degrading enzyme (IDE), amyloid beta-protein (Abeta) and insulin, are critically important in the… Expand
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Highly Cited
2003
Highly Cited
2003
Converging evidence suggests that the accumulation of cerebral amyloid beta-protein (Abeta) in Alzheimer's disease (AD) reflects… Expand
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Highly Cited
2002
Highly Cited
2002
Although extensive data support a central pathogenic role for amyloid β protein (Aβ) in Alzheimer's disease, the amyloid… Expand
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Highly Cited
2000
Highly Cited
2000
Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Abeta, the principal component of… Expand
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Highly Cited
2000
Highly Cited
2000
Progressive cerebral accumulation of amyloid β-protein (Aβ) is an early and invariant feature of Alzheimer's disease. Little is… Expand
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Highly Cited
1998
Highly Cited
1998
Excessive cerebral accumulation of the 42-residue amyloid β-protein (Aβ) is an early and invariant step in the pathogenesis of… Expand
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