Insulinase

Known as: Protease, Insulin, Insulin Degrading Enzyme, Insulysin 
An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
The pathological hallmark of Alzheimer disease is the senile plaque principally composed of tightly aggregated amyloid-beta… (More)
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Highly Cited
2006
Highly Cited
2006
The thiazolidinediones, such as rosiglitazone, increase peripheral insulin sensitivity and their use is proposed for the… (More)
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Highly Cited
2005
Highly Cited
2005
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there are few therapeutics that affect the… (More)
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Highly Cited
2004
Highly Cited
2004
Recent epidemiological evidence indicates that insulin resistance, a proximal cause of Type II diabetes [a non-insulin dependent… (More)
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Highly Cited
2003
Highly Cited
2003
Two substrates of insulin-degrading enzyme (IDE), amyloid beta-protein (Abeta) and insulin, are critically important in the… (More)
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Highly Cited
2003
Highly Cited
2003
Converging evidence suggests that the accumulation of cerebral amyloid beta-protein (Abeta) in Alzheimer's disease (AD) reflects… (More)
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Highly Cited
2003
Highly Cited
2003
Two substrates of insulin-degrading enzyme (IDE), amyloid -protein (A ) and insulin, are critically important in the pathogenesis… (More)
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Highly Cited
2002
Highly Cited
2002
Although extensive data support a central pathogenic role for amyloid β protein (Aβ) in Alzheimer's disease, the amyloid… (More)
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Highly Cited
2001
Highly Cited
2001
Alzheimer's Disease (AD) is characterized by cerebral accumulation of beta-amyloid peptides (Abeta), which are proteolytically… (More)
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Highly Cited
1998
Highly Cited
1998
Excessive cerebral accumulation of the 42-residue amyloid beta-protein (Abeta) is an early and invariant step in the pathogenesis… (More)
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