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Insulinase

Known as: Protease, Insulin, Insulin Degrading Enzyme, Insulysin 
An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10… 
National Institutes of Health

Related topics

Related topics

20 relations
Alzheimer's Disease Pathway KEGGCytoplasmEnzyme GeneExtracellular Space

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Disease
Galactic Cosmic Radiation consisting of high-energy, high-charged (HZE) particles poses a significant threat to future astronauts… 
Highly Cited
2012
Highly Cited
2012
Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease
Although evidence is accumulating that diabetes mellitus is an important risk factor for sporadic Alzheimer's disease (AD), the… 
Highly Cited
2011
Highly Cited
2011
Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-β neurotoxicity.
Highly Cited
2008
Highly Cited
2008
IL-4-Induced Selective Clearance of Oligomeric β-Amyloid Peptide1–42 by Rat Primary Type 2 Microglia1
A hallmark of immunopathology associated with Alzheimer’s disease is the presence of activated microglia (MG) surrounding senile… 
Highly Cited
2006
Highly Cited
2006
Regulation of Steady-state β-Amyloid Levels in the Brain by Neprilysin and Endothelin-converting Enzyme but Not Angiotensin-converting Enzyme*
The deposition of β-amyloid in the brain is a pathological hallmark of Alzheimer disease (AD). Normally, the accumulation of… 
Highly Cited
2006
Highly Cited
2006
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism
Insulin-degrading enzyme (IDE), a Zn2+-metalloprotease, is involved in the clearance of insulin and amyloid-β (refs 1–3). Loss-of… 
Highly Cited
2003
Highly Cited
2003
Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death
Review
2002
Review
2002
β‐Amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?
The steady‐state level of amyloid β‐peptide (Aβ) represents a balance between its biosynthesis from the amyloid precursor protein… 
Review
1984
Review
1984
The renal metabolism of insulin
SummaryThe kidney plays a pivotal role in the clearance and degradation of circulating insulin and is also an important site of… 
Review
1981
Review
1981
Insulin metabolism and degradation.
INSULIN degradation is a complex and incompletely, understood process at present. In terms of overall clearance and metabolism… 
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