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Guanylin: an endogenous activator of intestinal guanylate cyclase.
- M. Currie, K. Fok, +4 authors C. Smith
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 February 1992
It is proposed that guanylin is an activator of intestinal guanylate cyclase and that it stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. Expand
Characterization of metalloprotease cleavage products of human articular cartilage.
- Eugene Y. Zhen, I. Brittain, +4 authors K. Duffin
- Chemistry, Medicine
- Arthritis and rheumatism
- 1 August 2008
Characterization of these cartilage matrix peptides may help in the development of pharmacodynamic biomarkers of cartilage degradation, and also may contribute to an understanding of the bioactive peptides important in chondrocyte signaling. Expand
Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.
It appears that employing a dietary or a combined dietary/pharmacological paradigm to augment the cellular ratio of DGLA/AA is not an effective route to enhance endogenous synthesis of P GE(1) over PGE(2), at least in cells/tissues where COX-1 predominates over COX -2. Expand
A Signature of Circulating Inflammatory Proteins and Development of End Stage Renal Disease in Diabetes
These findings provide strong evidence that KRIS proteins contribute to the inflammatory process underlying end-stage renal disease development in both types of diabetes, and point to new therapeutic targets and new prognostic tests to identify subjects at risk of end-Stage renal disease. Expand
Electrospray and tandem mass spectrometric characterization of acylglycerol mixtures that are dissolved in nonpolar solvents.
Electrospray mass spectrometric analysis of mixtures containing monoglycerides, diglycerides, and triglycerides revealed that acylglycerols that contained unsaturated fatty acid chains were observed to exhibit a response in the mass spectrum greater than those with saturated chains, and ion signals resulting from the molecular adduct ions of monoglycersides were more abundant than those of diglyceride, which were more scarce in themass spectrum. Expand
Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.
Molecular Chlorine Generated by the Myeloperoxidase-Hydrogen Peroxide-Chloride System of Phagocytes Converts Low Density Lipoprotein Cholesterol into a Family of Chlorinated Sterols*
- S. L. Hazen, F. Hsu, K. Duffin, J. Heinecke
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 20 September 1996
Cl2 derived from HOCl is the chlorinating intermediate in the oxidation of cholesterol by myeloperoxidase, and observations suggest that Cl2 generation in acidic compartments may constitute one pathway for oxidation of LDL cholesterol in the artery wall. Expand
Characterization of N-linked oligosaccharides by electrospray and tandem mass spectrometry.
The composition and relative abundances of individual oligosaccharides obtained from the electrospray mass spectrum compare favorably to those obtained by anion-exchange chromatography/pulsed amperometric detection and by gel permeation chromatography of the oligosACcharides after radiolabelling the reducing end of the carbohydrates. Expand
Characterization of human uroguanylin: a member of the guanylin peptide family.
- T. Kita, C. Smith, +7 authors L. Forte
- Biology, Medicine
- The American journal of physiology
- 1 February 1994
The isolation from human urine of a unique peptide, uroguanylin, that behaves in a manner similar to guanylin and appears to be a new member of this peptide family is reported. Expand
Activity of two-chain recombinant human cytomegalovirus protease.
- B. Holwerda, A. Wittwer, +5 authors M. Bryant
- Medicine, Chemistry
- The Journal of biological chemistry
- 14 October 1994
The human cytomegalovirus UL80 protease was expressed in Escherichia coli and purified by metal-chelate chromatography using a histidine tag engineered at the amino terminus, resulting in the recovery of 16- plus 14-kDa two-chain protease. Expand