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ICI 198583

Known as: ICI-198583, ICI198583 
 
National Institutes of Health

Papers overview

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2006
2006
We describe the characterization of human lymphoblastoid cell lines with acquired resistance (>20,000-fold) to a novel folate… Expand
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Review
1998
Review
1998
Thymidylate synthase (TS), an enzyme that catalyses the conversion of dUMP to dTMP, has been the focus of interest as a target in… Expand
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1998
1998
CB30865 (p-[N-(7-bromo-3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl+ ++)-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide… Expand
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1997
1997
In an effort to synthesize inhibitors of thymidylate synthase (TS) that do not undergo polyglutamation, a series of gamma-linked… Expand
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1996
1996
Prodrugs of quinazoline antifolate thymidylate synthase (TS) inhibitors have been designed and synthesized for use in antibody… Expand
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1996
1996
The syntheses of gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid… Expand
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1992
1992
We describe the characterization of human lymphoblastoid cell lines with acquired resistance (greater than 20,000-fold) to a… Expand
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1991
1991
2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) is a more water-soluble analogue of the quinazoline-based… Expand
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1991
1991
5,10-Dideazatetrahydrofolate (DDATHF) is an antifolate drug, the cytotoxic effects of which can be fully reversed by hypoxanthine… Expand
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Review
1991
Review
1991
Heterocyclic para-aminobenzoate modifications of 2-desamino-2-methyl-5,8-dideazafolic acid and a series of its N10-substituted… Expand
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