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ICI 198583

Known as: ICI-198583, ICI198583 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Antineoplastic AgentsEnzyme InhibitorsFolic AcidFolic Acid Antagonists
analogs & derivatives

Papers overview

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2002
2002
Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid.
2-Deamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) is a potent inhibitor of thymidylate synthase. Its analogue… 
2002
2002
Synthesis and biological activity of Na-[ 4-[ N-[ ( 3 , 4-dihydro-2-methyl-4-oxo-6-quinazolinyl ) methyl ]-N-propargylamino ] phenyl-acetyl ]-L-glutamic acid
2-Deamino-2-methyl-N 10 -propargyl-5,8-dideazafolic acid (ICI 198583) is a potent inhibitor of thymidylate synthase. Its analogue… 
Review
1998
Review
1998
Nonpolyglutamatable antifolates as inhibitors of thymidylate synthase (TS) and potential antitumour agents.
Thymidylate synthase (TS), an enzyme that catalyses the conversion of dUMP to dTMP, has been the focus of interest as a target in… 
1996
1996
Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
The syntheses of gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid… 
1995
1995
Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation.
Quinazoline-based analogues of folic acid are a group of thymidylate synthase (TS) inhibitors that display a wide spectrum of… 
1994
1994
The synthesis and thymidylate synthase inhibitory activity of L-gamma-L-linked dipeptide and L-gamma-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Sixteen gamma-linked dipeptide and four L-Glu-gamma-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid… 
1993
1993
The in vivo metabolic stability of dipeptide analogues of the quinazoline antifolate, ICI 198583, in mice.
1991
1991
Inhibition of 2-desamino-2-methyl-10-propagyl-5,8-dideazafolic acid cytotoxicity by 5,10-dideazatetrahydrofolate in L1210 cells with decrease in DNA fragmentation and deoxyadenosine triphosphate…
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