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ICI 198583

Known as: ICI-198583, ICI198583 
 
National Institutes of Health

Papers overview

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2006
2006
We describe the characterization of human lymphoblastoid cell lines with acquired resistance (>20,000-fold) to a novel folate… Expand
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Review
1998
Review
1998
Thymidylate synthase (TS), an enzyme that catalyses the conversion of dUMP to dTMP, has been the focus of interest as a target in… Expand
1998
1998
CB30865 (p-[N-(7-bromo-3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl+ ++)-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide… Expand
1997
1997
In an effort to synthesize inhibitors of thymidylate synthase (TS) that do not undergo polyglutamation, a series of gamma-linked… Expand
1996
1996
Prodrugs of quinazoline antifolate thymidylate synthase (TS) inhibitors have been designed and synthesized for use in antibody… Expand
1993
1993
In the search for quinazoline thymidylate synthase inhibitors that are not subject to intracellular polyglutamation, a class of… Expand
1992
1992
We describe the characterization of human lymphoblastoid cell lines with acquired resistance (greater than 20,000-fold) to a… Expand
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Highly Cited
1991
Highly Cited
1991
2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) is a more water-soluble analogue of the quinazoline-based… Expand
1991
1991
5,10-Dideazatetrahydrofolate (DDATHF) is an antifolate drug, the cytotoxic effects of which can be fully reversed by hypoxanthine… Expand
Review
1991
Review
1991
Heterocyclic para-aminobenzoate modifications of 2-desamino-2-methyl-5,8-dideazafolic acid and a series of its N10-substituted… Expand