Hydroxysteroid Dehydrogenases

The metabolic syndrome (visceral obesity, insulin resistance, type 2 diabetes, and dyslipidemia) resembles Cushing's Syndrome… (More)

In obese humans and rodents there is increased expression of the key glucocorticoid (GC) regenerating enzyme, 11beta… (More)

Excess tissue glucocorticoid action may underlie the dyslipidemia, insulin resistance, and impaired glucose tolerance of the… (More)

The adverse metabolic consequences of obesity are best predicted by the quantity of visceral fat. Excess glucocorticoids produce… (More)

Glucocorticoid hormones, acting via nuclear receptors, regulate many metabolic processes, including hepatic gluconeogenesis. It… (More)

OBJECTIVE Placental 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), which converts active cortisol to inactive cortisone, has… (More)

Recent epidemiological studies have linked low birth weight with the later occurrence of cardiovascular and metabolic disorders… (More)

The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) is thought to protect the non-selective mineralocorticoid receptor… (More)

In vitro the mineralocorticoid receptor is non-specific and does not distinguish between aldosterone and cortisol. In vivo… (More)

The sodium retention associated with liquorice ingestion has been thought to be due to a direct mineralocorticoid effect, despite… (More)