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11-beta-Hydroxysteroid Dehydrogenases

Known as: Dehydrogenase, 11beta-Hydroxysteroid, 11 beta Hydroxysteroid Dehydrogenases, Cortisone 11 Oxoreductase 
Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can… 
National Institutes of Health

Related topics

Related topics

10 relations
11-beta-hydroxysteroid dehydrogenase activityIn BloodProcess of secretionantagonists & inhibitors

Narrower (1)

Cortisone reductase deficiency

Broader (1)

Hydroxysteroid Dehydrogenases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion
The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo… 
Highly Cited
2003
Highly Cited
2003
Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians.
Metabolic effects of cortisol may be critically modulated by glucocorticoid metabolism in tissues. Specifically, active cortisol… 
Review
2001
Review
2001
Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms
Highly Cited
2001
Highly Cited
2001
Modulation of 11β‐Hydroxysteroid Dehydrogenase Isozymes by Proinflammatory Cytokines in Osteoblasts: An Autocrine Switch from Glucocorticoid Inactivation to Activation
Tissue damage by proinflammatory cytokines is attenuated at both systemic and cellular levels by counter anti‐inflammatory… 
Highly Cited
2000
Highly Cited
2000
Topical corticosteroid phobia in patients with atopic eczema
Topical corticosteroids are widely prescribed by dermatologists caring for patients with atopic eczema. Patients’ fears about… 
Highly Cited
1997
Highly Cited
1997
Placental 11β‐hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure
OBJECTIVE Placental 11β‐hydroxysteroid dehydrogenase (11β‐HSD), which converts active cortisol to inactive cortisone, has been… 
Highly Cited
1994
Highly Cited
1994
Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase.
BACKGROUND Hyperandrogenemia is the hallmark of the polycystic ovary syndrome, yet the relative contributions of the adrenal… 
Highly Cited
1994
Highly Cited
1994
11 beta-Hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells.
Leydig cells from mature rat testes contain high levels of 11 beta-hydroxysteroid dehydrogenase (11HSD), an enzyme that… 
Highly Cited
1993
Highly Cited
1993
Cessation of long-term treatment with inhaled corticosteroid (budesonide) in children with asthma results in deterioration. The Dutch CNSLD Study Group.
Inhaled corticosteroid has been shown to be effective in the management of asthma. However, there is a lack of studies that… 
Highly Cited
1990
Highly Cited
1990
Expression of 11 beta-hydroxysteroid dehydrogenase using recombinant vaccinia virus.
Ligand specificity of the type I steroid receptor is apparently conferred by the activity of 11 beta-hydroxysteroid dehydrogenase… 
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