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11-beta-Hydroxysteroid Dehydrogenases

Known as: Dehydrogenase, 11beta-Hydroxysteroid, 11 beta Hydroxysteroid Dehydrogenases, Cortisone 11 Oxoreductase 
Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND Lower activity of 11 beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) classically induces hypertension by leading to… Expand
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Highly Cited
2004
Highly Cited
2004
The metabolic syndrome (visceral obesity, insulin resistance, type 2 diabetes, and dyslipidemia) resembles Cushing's Syndrome… Expand
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Highly Cited
2004
Highly Cited
2004
Whether the negative impact of excess glucocorticoids on the skeleton is due to direct effects on bone cells, indirect effects on… Expand
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Highly Cited
2001
Highly Cited
2001
The adverse metabolic consequences of obesity are best predicted by the quantity of visceral fat. Excess glucocorticoids produce… Expand
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Highly Cited
2000
Highly Cited
2000
Topical corticosteroids are widely prescribed by dermatologists caring for patients with atopic eczema. Patients’ fears about… Expand
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Highly Cited
1998
Highly Cited
1998
Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The molecular mechanisms underlying… Expand
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Highly Cited
1996
Highly Cited
1996
Glucocorticoids play important roles in development and 'fetal programming'. Fetal exposure to excess glucocorticoids reduces… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND It has been proposed that aldosterone exerts direct effects on heart function, most notably on the development of… Expand
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Highly Cited
1994
Highly Cited
1994
The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) is thought to protect the non-selective mineralocorticoid receptor… Expand
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Highly Cited
1991
Highly Cited
1991
The Type I (mineralocorticoid) receptor has identical affinities in vitro for cortisol and aldosterone. It has been suggested… Expand
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