11-beta-hydroxysteroid dehydrogenase activity

Known as: corticosteroid 11-reductase, 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity, dehydrogenase, 11beta-hydroxy steroid 
Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+). [EC:1.1.1.146, PMID:15761036]

Topic mentions per year

Topic mentions per year

1966-2017
05010019662017

Papers overview

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Highly Cited
2006
Highly Cited
2006
The local generation of active glucocorticoid by NADPH-dependent, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1… (More)
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2004
2004
This work studied the effect of stresses produced by simulated gavage or gavage with 200 mmol/L HCl two hours before adrenal… (More)
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Highly Cited
2004
Highly Cited
2004
In obese humans and rodents there is increased expression of the key glucocorticoid (GC) regenerating enzyme, 11beta… (More)
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Highly Cited
2004
Highly Cited
2004
Whether the negative impact of excess glucocorticoids on the skeleton is due to direct effects on bone cells, indirect effects on… (More)
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Highly Cited
2001
Highly Cited
2001
Cortisol has been implicated as a pathophysiological mediator in idiopathic obesity, but circulating cortisol concentrations are… (More)
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Highly Cited
2001
Highly Cited
2001
Excess tissue glucocorticoid action may underlie the dyslipidemia, insulin resistance, and impaired glucose tolerance of the… (More)
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2001
2001
Glycyrrhizic acid is widely applied as a sweetener in food products and chewing tobacco. Habitual consumption of this compound… (More)
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Highly Cited
1998
Highly Cited
1998
Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The molecular mechanisms underlying… (More)
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1995
1995
Male Wistar rats were treated with different ethanol concentrations diluted in drinking water in order to evaluate the effect of… (More)
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1993
1993
OBJECTIVE 11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD), by converting the active steroids cortisol and corticosterone to… (More)
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