Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia.
Findings revealed that both women and men have higher levels of receptors and 5alpha-reductase type I and II in frontal hair follices than in occipital follicles, whereasHigher levels of aromatase were found in their occipITAL follicles.
Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne
The data suggest that CAG-repeat length in AR may affect androgen mediated gene expression in hair follicles and sebaceous glands in men and women with these androgenic skin disorders.
Although the definition of idiopathic hirsutism has been an evolving process, the diagnosis of IH should be applied only to hirsute patients with normal ovulatory function and circulating androgen levels, and patients respond to antiandrogen or 5alpha-RA inhibitor therapy.
Androgenetic alopecia. New approved and unapproved treatments.
Androgen responsive genes as they affect hair growth.
Results from this study indicate caspase 3 to be of primary importance in normal hair homeostasis and that DHT may be signaling greater expression of caspases, inducing apoptosis in androgenetic alopecia.
Immunohistochemical distribution of aromatase and 3B‐hydroxysteroid dehydrogenase in human hair follicle and sebaceous gland
It is hypothesized that AR may be one of many enzymes or factors that play a role in the HF cycle by regulating the level of androgens formed locally, whereas 3B‐HSD is localized in SG, converting weak androgen precursors to potent androgens, stimulating lipogenesis.
Purification of androgen receptors in human sebocytes and hair.
- M. Sawaya
- BiologyJournal of Investigative Dermatology
- 1 June 1992
Human sebaceous glands (SG) and hair follicles (HF) are target structures in the skin for androgen action. They contain steroid enzymes, capable of transforming weak androgens into the…
Androgenetic Alopecia: Overview
- M. Sawaya
- Medicine, BiologyJournal of cutaneous medicine and surgery
- 1 November 1999
Research in the last few years has shown that on the scalp there are local differences in the amounts of steroid metabolizing enzymes that convert weak androgens to more potent androgens, which is an important concept since the skin is an endocrine target tissue for androgen hormone action.
Atlas of Hair and Nails
The nail nail signs of systemic disease fungal infections common hair loss disorders hair shaft abnormalities hirsutism and hyperstrichosis cicatricial alopecias tumours ofhair and nails pigment disorders of hair and nails special issues adverse effects and drug interactions of medications used to treathair and nail disorders ageing forensic and medicolegal issues psychiatric issues molecular basis of inherited hair and nail diseases.