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Histone Deacetylation

Histone Deacetylation is the covalent post-translational enzymatic addition of an acetyl group(s) to a histone protein. By exposing cationic sites on… 
National Institutes of Health

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HDAC1 protein, humanHDAC10 geneHDAC10 wt AlleleHDAC11 gene

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histone deacetylase activity

Papers overview

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2011
2011
Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).
Highly Cited
2006
Highly Cited
2006
Cardiac histones are substrates of histone deacetylase activity in hemorrhagic shock and resuscitation.
2006
2006
Inhibition of histone deacetylation protects wild‐type but not gelsolin‐deficient neurons from oxygen/glucose deprivation
Histone acetylation and deacetylation participate in the epigenetic regulation of gene expression. In this paper, we demonstrate… 
Highly Cited
2004
Highly Cited
2004
DNA Methyltransferase 1 Knock Down Induces Gene Expression by a Mechanism Independent of DNA Methylation and Histone Deacetylation*
DNA methyltransferase 1 (DNMT1) catalyzes the post-replication methylation of DNA and is responsible for maintaining the DNA… 
Highly Cited
2004
Highly Cited
2004
Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression.
Site-specific modification of nucleosomal histones plays a central role in the formation of transcriptionally active and inactive… 
2003
2003
Histone Deacetylation, But Not Hypermethylation, Modifies Class II Transactivator and MHC Class II Gene Expression in Squamous Cell Carcinomas1
In this study, we first categorized nine squamous cell carcinoma (SCC) cell lines into two groups in terms of the expression of… 
Highly Cited
2002
Highly Cited
2002
Retinoblastoma Protein Transcriptional Repression through Histone Deacetylation of a Single Nucleosome
ABSTRACT The retinoblastoma protein, pRb, controls transcription through recruitment of histone deacetylase to particular E2F… 
2002
2002
Activation of silenced transgene expression in neural precursor cell lines by inhibitors of histone deacetylation
Ex vivo gene therapy in the central nervous system (CNS) holds great promise for diseases such as the neurodegenerative disorders… 
Highly Cited
2001
Highly Cited
2001
MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome.
Rett syndrome (RTT) is a mostly sporadic disorder of developmental regression, with loss of speech and purposeful hand use… 
2001
2001
Steroid Hormone Receptor-mediated Histone Deacetylation and Transcription at the Mouse Mammary Tumor Virus Promoter*
Acetylation of lysines in histones H3 and H4 N-terminal tails is associated with transcriptional activation and deacetylation… 
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