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histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group… 
National Institutes of Health

Papers overview

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2018
2018
Abstract The role of epigenetic alterations during cancer has gained increasing attention and has resulted in a paradigm shift in… 
2017
2017
The study described herein aimed to evaluate the impact of exercise on histone acetylation markers in striatum from Wistar rats… 
Highly Cited
2012
Highly Cited
2012
A tetraphenylethylene-derivative fluorescent probe for the one-step detection of histone deacetylases (HDAC) was developed. The… 
2003
2003
Chromatin silencing is the inactivation of large domains of DNA by packaging them into a specialized inaccessible chromatin… 
Highly Cited
2000
Highly Cited
2000
The anticancer effects of retinoids are mainly mediated by two classes of nuclear receptors, the retinoic acid receptors (RARs… 
2000
2000
Alterations in histone acetylation status appear to play a central role in the regulation of neoplasia, tumor suppression, cell… 
1999
1999
Abstract We have investigated the effects of inhibition of histone de-acetylase activity on silencing at the silent mating-type…