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histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group… 
National Institutes of Health

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3 relations
Histone Deacetylasehistone deacetylase inhibitor activity

Broader (1)

Histone Deacetylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Sulforaphane absorption and histone deacetylase activity following single dosing of broccoli sprout supplement in normal dogs
Abstract The role of epigenetic alterations during cancer has gained increasing attention and has resulted in a paradigm shift in… 
2017
2017
Differential effect of treadmill exercise on histone deacetylase activity in rat striatum at different stages of development
The study described herein aimed to evaluate the impact of exercise on histone acetylation markers in striatum from Wistar rats… 
2017
2017
Dimeric but not monomeric α-lactalbumin potentiates apoptosis by up regulation of ATF3 and reduction of histone deacetylase activity in primary and immortalised cells.
Highly Cited
2012
Highly Cited
2012
A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission.
A tetraphenylethylene-derivative fluorescent probe for the one-step detection of histone deacetylases (HDAC) was developed. The… 
2012
2012
BCR-ABL1 kinase facilitates localization of acetylated histones 3 and 4 on DNA double-strand breaks.
2003
2003
[The histone deacetylase activity of SIR2 and chromatin silencing].
Chromatin silencing is the inactivation of large domains of DNA by packaging them into a specialized inaccessible chromatin… 
2002
2002
Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos…
REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c… 
Highly Cited
2000
Highly Cited
2000
Unique anti-activator protein-1 activity of retinoic acid receptor beta.
The anticancer effects of retinoids are mainly mediated by two classes of nuclear receptors, the retinoic acid receptors (RARs… 
2000
2000
Promoter specific sensitivity to inhibition of histone deacetylases: implications for hormonal gene control, cellular differentiation and cancer.
Alterations in histone acetylation status appear to play a central role in the regulation of neoplasia, tumor suppression, cell… 
1999
1999
Transient inhibition of histone deacetylase activity overcomes silencing in the mating-type region in fission yeast
Abstract We have investigated the effects of inhibition of histone de-acetylase activity on silencing at the silent mating-type… 
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