histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to induce histone hyperacetylation and… (More)
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Highly Cited
2011
Highly Cited
2011
The anti-skin carcinogenic effects of green tea catechins have been studied extensively in vitro and in vivo models but the… (More)
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Highly Cited
2007
Highly Cited
2007
Histone acetylation plays an important role in regulating gene expressions by modulating chromatin structure. Histone deacetylase… (More)
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Highly Cited
2007
Highly Cited
2007
Recently, it was demonstrated that lineage-committed oligodendrocyte precursor cells (OPCs) can be converted to multipotent… (More)
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2004
2004
Adipogenesis is dependent on the sequential activation of transcription factors including the CCAAT/enhancer-binding proteins (C… (More)
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Highly Cited
2000
Highly Cited
2000
The DNA methyltransferase Dnmt1 is responsible for cytosine methylation in mammals and has a role in gene silencing. DNA… (More)
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Highly Cited
2000
Highly Cited
2000
We have previously shown that Ikaros can repress transcription through the recruitment of histone deacetylase complexes. Here we… (More)
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Highly Cited
1998
Highly Cited
1998
Treatment of mammalian cells with small molecule histone deacetylase (HDAC) inhibitors induces changes in the transcription of… (More)
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Highly Cited
1998
Highly Cited
1998
Eukaryotic organisms from yeast to human contain a multiprotein complex that includes Rpd3 histone deacetylase and Sin3… (More)
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Highly Cited
1998
Highly Cited
1998
Position-effect control at the silent mat2-mat3 interval and at centromeres and telomeres in fission yeast is suggested to be… (More)
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