histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group… (More)
National Institutes of Health

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Histone Deacetylasehistone deacetylase inhibitor activity

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Histone Deacetylation

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Highly Cited
2012
Highly Cited
2012
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to induce histone hyperacetylation and… (More)
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Highly Cited
2011
Highly Cited
2011
(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells.
The anti-skin carcinogenic effects of green tea catechins have been studied extensively in vitro and in vivo models but the… (More)
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Highly Cited
2007
Highly Cited
2007
Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells.
Histone acetylation plays an important role in regulating gene expressions by modulating chromatin structure. Histone deacetylase… (More)
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Highly Cited
2007
Highly Cited
2007
Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells.
Recently, it was demonstrated that lineage-committed oligodendrocyte precursor cells (OPCs) can be converted to multipotent… (More)
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2004
2004
Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis.
Adipogenesis is dependent on the sequential activation of transcription factors including the CCAAT/enhancer-binding proteins (C… (More)
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Highly Cited
2000
Highly Cited
2000
DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
The DNA methyltransferase Dnmt1 is responsible for cytosine methylation in mammals and has a role in gene silencing. DNA… (More)
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Highly Cited
2000
Highly Cited
2000
Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.
We have previously shown that Ikaros can repress transcription through the recruitment of histone deacetylase complexes. Here we… (More)
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Highly Cited
1998
Highly Cited
1998
A role for histone deacetylase activity in HDAC1-mediated transcriptional repression.
Treatment of mammalian cells with small molecule histone deacetylase (HDAC) inhibitors induces changes in the transcription of… (More)
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Highly Cited
1998
Highly Cited
1998
Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.
Eukaryotic organisms from yeast to human contain a multiprotein complex that includes Rpd3 histone deacetylase and Sin3… (More)
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Highly Cited
1998
Highly Cited
1998
Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast.
Position-effect control at the silent mat2-mat3 interval and at centromeres and telomeres in fission yeast is suggested to be… (More)
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