Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter

@article{Kukushkin2002DownregulationOC,
  title={Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter},
  author={Alexander N Kukushkin and Maria V. Abramova and S. B. Svetlikova and Zalfia A Darieva and Tatyana V. Pospelova and V. A. Pospelov},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={719-730}
}
REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c-Fos protein. Consistently, the transcription of c-fos gene has been found to be downregulated. To elucidate the mechanisms of c-fos downregulation in E1A+cHa-ras transformants, we studied the levels of activity of ERK, JNK/SAPK and p38 kinases and phosphorylation state of Elk-1 transcription factor involved in regulation of c-fos gene. Using two approaches, Western… CONTINUE READING

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References

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Showing 1-6 of 6 references

J

H Zhang, X Shi, M Hampong, L Blanis, S. Pelech
Biol. Chem., 276, 6905 ± 6908. • 2001

Curr

T. Kouzarides
Opin. Genet. Dev., 9, 40 ± 48. • 1999
View 1 Excerpt

Oncogene, 18, 5611 ± 5619

Pospelova TV.
Chomczynski P and Sacchi N. (1987). Analyt. Biochem., 162, • 1999

Oncogene, 15, 2321 ± 2331

LS.
Herrera RE, Shaw PE and Nordheim A. (1989). Nature, 340, • 1997

Proc

JK Westwick, AD Cox, +4 authors DA. Brenner
Natl. Acad. Sci. USA, 91, 6030 ± 6034. • 1994

Mol

CL Yu, EV Prochownik, MJ Imperiale, R. Jove
Cell. Biol., 13, 2011 ± 2019. • 1993

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