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histone deacetylase inhibitor activity

Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to… Expand
National Institutes of Health

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histone deacetylase activity

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2019
2019
Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells
BackgroundGlioblastoma multiforme (GBM) is the most severe type of primary brain tumor with a high mortality rate. Although… Expand
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2016
2016
Opposing effects of valproic acid treatment mediated by histone deacetylase inhibitor activity in four transgenic X. laevis models of retinitis pigmentosa.
Retinitis pigmentosa (RP) is an inherited retinal degeneration (RD) that leads to blindness for which no treatment is available… Expand
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2015
2015
Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity
Chemo- and radiotherapy cause multiple forms of DNA damage and lead to the death of cancer cells. Inhibitors of the DNA damage… Expand
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2015
2015
Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids.
The combination of (1α,25)-dihydroxyvitamin D3 (1,25D) and histone deacetylase inhibitor (HDACi) trichostatin A is highly… Expand
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2008
2008
Short-chain fatty acids and trichostatin A alter tight junction permeability in human umbilical vein endothelial cells.
OBJECTIVE The short-chain fatty acids (SCFAs), butyrate, propionate, and acetate, produced by bacterial fermentation of dietary… Expand
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