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Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC or UICCTNM classification.
Cancer classification using the Immunoscore: a worldwide task force
Evidence supports the notion to include immunological biomarkers, implemented as a tool for the prediction of prognosis and response to therapy, into traditional classification of cancer, designated TNM-I (TNM-Immune), and introduction of this parameter as a biomarker to classify cancers will facilitate clinical decision-making.
Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast
It was revealed that the survivin protein level was up-regulated by the coexpression of HER2 and EGFR, leading to the increased resistance against etoposide-induced apoptosis in breast cancer cells, and survivin levels and apoptosis resistance were decreased when cells were treated with Herceptin.
Prognostic significance of HLA class I expression in osteosarcoma defined by anti‐pan HLA class I monoclonal antibody, EMR8‐5
Findings suggest that the class I‐restricted cytotoxic T lymphocyte pathway plays a major role in immune surveillance of patients with osteosarcoma.
Anisakidae and anisakidosis.
During the 1950s, Ishikura noticed in the fishing town of Iwanai, Hokkaido, an intestinal disease that frequently occurred in winter with clinical and histopathologic characteristics different from
SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity
Observations indicate that SOX2 has a role in maintenance of stemness and tumorigenicity of human lung adenocarcinoma CSCs/CICs and is a potential target for treatment.
Ovarian Cancer Stem Cells Are Enriched in Side Population and Aldehyde Dehydrogenase Bright Overlapping Population
SP cells and aldehyde dehydrogenese bright cells from ovarian cancer cells are analyzed and use of the SP and ALDHBr overlapping population is a promising approach to isolate highly purified CSCs/CICs and SOX2 might be a novel functional marker for ovarian CSC/C ICs.
β‐Catenin gene mutation in human hair follicle‐related tumors
The results seem to indicate that hair matrix cells are key players in hair development, as investigation into gene abnormalities of hair‐follicle tumors may elucidate the cause of their neoplastic transformation, and may provide a suggestion for the mechanism of hair development.