High-Molecular-Weight Kininogen protein

Known as: Kininogen, High-Molecular-Weight [Chemical/Ingredient], Fitzgerald Factor, Kininogen.high molecular weight 
A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein… (More)
National Institutes of Health

Related topics

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Narrower (1)

High molecular weight kininogen deficiency
In BloodKNG1 geneKininogen-1, humanProcess of secretion
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Broader (1)

Kininogens

Papers overview

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2002
2002
Elevated levels of plasma prekallikrein, high molecular weight kininogen and factor XI in coronary heart disease.
Increased levels of hemostatic factors may play a role in the pathogenesis of myocardial infarction by triggering thrombin… (More)
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2001
2001
Regulation of leukocyte recruitment by polypeptides derived from high molecular weight kininogen.
Proteolytic cleavage of single-chain, high molecular weight kininogen (HK) by kallikrein releases the short-lived vasodilator… (More)
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Highly Cited
2000
Highly Cited
2000
Domain 5 of high molecular weight kininogen (kininostatin) down-regulates endothelial cell proliferation and migration and inhibits angiogenesis.
We have demonstrated that high molecular weight kininogen (HK) binds specifically on endothelial cells to domain 2/3 of the… (More)
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1993
1993
Deletion mutagenesis of high molecular weight kininogen light chain. Identification of two anionic surface binding subdomains.
The light chain (LC) of cleaved high molecular weight kininogen (HK) binds to anionic surfaces as well as the zymogens… (More)
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1989
1989
High molecular weight kininogen inhibits fibrinogen binding to cytoadhesins of neutrophils and platelets
Fibrinogen inhibited 125I-high molecular weight kininogen (HMWK) binding and displaced bound 125I-HMWK from neutrophils. Studies… (More)
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1988
1988
The expression of high molecular weight kininogen on human umbilical vein endothelial cells.
High molecular weight kininogen (HMWK) functions as a cofactor for activation of plasma serine zymogens and as an inhibitor of… (More)
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1986
1986
High molecular weight kininogen binds to unstimulated platelets.
Studies were performed to determine if the unstimulated platelet membrane has a site for high molecular weight kininogen (HMWK… (More)
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Highly Cited
1983
Highly Cited
1983
Prekallikrein activation and high-molecular-weight kininogen consumption in hereditary angioedema.
Patients with hereditary angioedema lack C-1 inhibitor, a plasma alpha 2-glycoprotein that inhibits both the proteolytic action… (More)
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1977
1977
Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein.
In the contact phase of activation of the kinin-forming, intrinsic clotting, and fibrinolytic systems, high-molecular-weight… (More)
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Highly Cited
1976
Highly Cited
1976
Identification of prekallikrein and high-molecular-weight kininogen as a complex in human plasma.
Prekallikrein and high-molecular-weight kininogen were found associated in normal human plasma at a molecular weight of 285,000… (More)
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