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A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice. Expand
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
- H. Maeda, J. Wu, T. Sawa, Y. Matsumura, K. Hori
- Biology, Medicine
- Journal of controlled release : official journal…
- 1 March 2000
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor. Expand
The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.
- H. Maeda
- Chemistry, Medicine
- Advances in enzyme regulation
- 1 May 2001
Genome sequencing and analysis of Aspergillus oryzae
Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation. Expand
The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect.
Molecular mechanisms of factors related to the EPR effect, the unique anatomy of tumor vessels, limitations and techniques to avoid such limitations, augmenting tumor drug delivery, and experimental and clinical findings are discussed. Expand
Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.
It was clarified that imidazolineoxyl N-oxide antagonize EDRF/.NO via a unique radical-radical reaction with .NO. Expand
Exploiting the enhanced permeability and retention effect for tumor targeting.
Various endogenous factors that can positively impact the EPR effect in tumor tissues are discussed, as well as practical methods available in the clinical setting for augmenting the effect by use of exogenous agents. Expand
Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology.
This report summarizes the workshop discussions on key issues of the EPR effect and major gaps that need to be addressed to effectively advance nanoparticle-based drug delivery. Expand
Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals.
- T. Akaike, Y. Noguchi, +5 authors H. Maeda
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 19 March 1996
It is concluded that NO together with O2- which forms more reactive peroxynitrite may be the most important pathogenic factors in influenza virus-induced pneumonia in mice. Expand
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo.
A historical review of the EPR effect, including its features, vascular mediators found in both cancer and inflamed tissue, and methods of augmentation of theEPR effect are described, that result in better tumor delivery and improved therapeutic effect. Expand