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High molecular weight kininogen deficiency

Known as: Fitzgerald factor deficiency, Williams factor deficiency, HMWK Deficiency 
A rare autosomal recessive inherited disorder characterized by prolonged partial thromboplastin time and absence of bleeding diathesis.
National Institutes of Health

Related topics

Related topics

7 relations

Broader (2)

Blood Coagulation DisordersHigh-Molecular-Weight Kininogen protein
Deficiency of coagulation factorsHematopoietic and Lymphoid CellHematopoietic and Lymphoid TissueInborn Errors of Metabolism

Papers overview

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2001
2001
High Molecular Weight Kininogen Deficiency: a Patient who Underwent Cardiac Surgery
Summary A 66 year old male, referred for cardiac surgery, was found to have high molecular weight kininogen deficiency (activity… 
Review
1990
Review
1990
Molecular genetic survey of five Japanese families with high-molecular-weight kininogen deficiency.
Analyses of the kininogen (KGN) molecule and KGN gene status in five Japanese families with high-molecular-weight (HMW) KGN… 
Highly Cited
1986
Highly Cited
1986
High molecular weight kininogen: localization in the unstimulated and activated platelet and activation by a platelet calpain(s).
High mol wt kininogen (HMWK), the major cofactor-substrate of the contact phase of coagulation, is contained within and secreted… 
1985
1985
Rat plasma high-molecular-weight kininogen. A simple method for purification and its characterization.
Review
1985
Review
1985
The role of nectar and oil in the pollination of Drymonia serrulata (Gesneriaceae) by Epicharis bees (Anthophoridae) in Panama
The pollination biology of Drymonia serrulata was studied in central Panama. D. serrulata produces a small number of flowers… 
Highly Cited
1982
Highly Cited
1982
Blood kinins, their concentration in normal subjects and in patients with congenital deficiency in plasma prekallikrein and kininogen.
Kinins are potent vasodilator peptides that may participate in the regulation of local blood flow and blood pressure. Here we… 
1981
1981
Abnormalities in the contact activation through factor XII in Fujiwara trait: a deficiency in both high and low molecular weight kininogens with low level of prekallikrein.
Fujiwara trait, the first case of kininogen deficiency in Japan previously reported which did not show any clinical symptom… 
Highly Cited
1979
Highly Cited
1979
Differential assay method for high molecular weight and low molecular weight kininogens.
1977
1977
Prekallikrein deficiency in a kindred with kininogen deficiency and Fitzgerald trait clotting defect. Evidence that high molecular weight kininogen and prekallikrein exist as a complex in normal…
Plasma from an individual with a hereditary deficiency of kininogens is deficient in kininogen antigens; heterozygous relatives… 
Highly Cited
1976
Highly Cited
1976
Radioimmunoassay of human Hageman factor (factor XII).
A secific, sensitive, and reproducible radioimmunoassay for human Hageman factor (HF, factory XII) has been developed with… 
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