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Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy.
Rat carrageenin-induced pleurisy was used to clarify the role of prostaglandin H synthase (PGHS)-2 in acute inflammation. Intrapleural injection of 0.2 ml of 2% lambda-carrageenin inducedExpand
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Release of adenosine in reactive hyperemia of the dog heart.
RUBQRAFAEL, ROBERT M. BERNE, AND MAKOTO KATORI. cardial hypoxia were imposed in these studies in order to liberate quantities of adenosine which could be detected by the techniques then available.Expand
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Cyclo‐oxygenase‐2 enhances basic fibroblast growth factor‐induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants
Angiogenesis is reportedly enhanced by prostaglandins (PGs). In the present study, we investigated whether or not cyclo‐oxygenase (COX)‐2 mediated angiogenesis in chronic and proliferate granuloma.Expand
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Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1.
We studied the anti-inflammatory activity of meloxicam on rat carrageenin-induced pleurisy and its toxicity for rat gastric mucosa, relative to its in vitro inhibitory potency against partiallyExpand
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Symmetry of matrix-valued stochastic processes and noncolliding diffusion particle systems
As an extension of the theory of Dyson’s Brownian motion models for the standard Gaussian random-matrix ensembles, we report a systematic study of Hermitian matrix-valued processes and theirExpand
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Evidence for the involvement of a plasma kallikrein‐kinin system in the immediate hypotension produced by endotoxin in anaesthetized rats
1 In vitro incubation of normal rat plasma with endotoxin from E. coli (3–10 mg ml−1 in the incubation mixture) caused a dose‐dependent increase in levels of free kinin and plasma kallikrein in theExpand
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Noncolliding Brownian Motion and Determinantal Processes
Abstract A system of one-dimensional Brownian motions (BMs) conditioned never to collide with each other is realized as (i) Dyson’s BM model, which is a process of eigenvalues of hermitianExpand
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High sensitivity to salt in kininogen-deficient brown Norway Katholiek rats.
Brown Norway Katholiek rats, which have very low levels of plasma kininogens, excreted a much smaller amount of kinin in the urine than normal rats of the same strain. The systolic blood pressure ofExpand
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Significant roles of inducible cyclooxygenase (COX)-2 in angiogenesis in rat sponge implants.
Angiogenesis in rat sponge implants, as determined from the concentration of hemoglobin in the sponge granuloma tissues, was gradually increased over a 14-day experimental period. The inducibleExpand
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Pivotal role of renal kallikrein-kinin system in the development of hypertension and approaches to new drugs based on this relationship.
Renal kallikrein is one of the tissue kallikreins, and the distal nephron is fully equipped as an element of the kallikrein-kinin system. Although a low excretion of urinary kallikrein has beenExpand
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